刚地弓形虫与线虫共感染的相互作用机制研究进展

吕芳丽; 林鑫埕

doi:10.12140/j.issn.1000-7423.2025.04.017

中国寄生虫学与寄生虫病杂志 >

2025 , Vol. 43 >Issue 4: 562 - 566

DOI: https://doi.org/10.12140/j.issn.1000-7423.2025.04.017

综述

刚地弓形虫与线虫共感染的相互作用机制研究进展

吕芳丽 ,
林鑫埕

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1 中山大学附属第七医院科研中心，广东深圳 518107
2 中山大学医学院寄生虫学教研室，广东深圳 518107
3 中山大学中山医学院寄生虫学教研室，广东广州 510080

吕芳丽（ORCID：0009-0002-6812-4133），女，医学博士，教授，从事弓形虫相关研究工作。E-mail：lvfangli@mail.sysu.edu.cn

收稿日期: 2024-11-16

修回日期: 2025-02-06

网络出版日期: 2025-10-09

基金资助

国家自然科学基金(82272366);国家自然科学基金(81971955);深圳市基础研究专项（自然科学基金）(JCYJ20220530145002006);广东省自然科学基金(2021A1515012115);广东省自然科学基金(2019A1515011667)

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Advances in the mechanism underlying the interaction of Toxoplasma gondii and nematodes co-infections

LV Fangli ,
LIN Xincheng

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1 Scientific Research Center, the Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, Guangdong, China
2 Department of Parasitology, School of Medicine, Sun Yat-sen University, Shenzhen 518107, Guangdong, China
3 Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, Guangdong, China

*E-mail: lvfangli@mail.sysu.edu.cn

Received date: 2024-11-16

Revised date: 2025-02-06

Online published: 2025-10-09

Supported by

National Natural Science Foundation of China(82272366);National Natural Science Foundation of China(81971955);Basic Research Fund in Shenzhen Natural Science Foundation(JCYJ20220530145002006);Natural Science Foundation of Guangdong Province(2021A1515012115);Natural Science Foundation of Guangdong Province(2019A1515011667)

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摘要

自然界中寄生虫共感染现象比较普遍，共感染既可影响宿主的免疫应答，也可影响寄生虫各自的发病机制。原虫和蠕虫可诱导不同的免疫应答，共感染可能会影响机体对这些寄生虫的免疫应答和感染的结局。刚地弓形虫是一种嗜神经原虫，可引起持续的亚临床神经炎症，与精神和神经退行性疾病以及其他疾病有关。迄今为止，有关弓形虫与线虫共感染相互作用机制的研究尚有限。本文综述了弓形虫与几种线虫（弓首蛔虫、旋毛虫、多形螺旋线虫和巴西日圆线虫）共感染在人或动物宿主中的相互作用机制。

关键词： 刚地弓形虫; 线虫; 共感染; 相互作用; 机制

本文引用格式

吕芳丽 , 林鑫埕 . 刚地弓形虫与线虫共感染的相互作用机制研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2025 , 43(4) : 562 -566 . DOI: 10.12140/j.issn.1000-7423.2025.04.017

Abstract

Parasitic co-infection is common in the natural world, which may affect both host immune responses and the pathogenesis of parasites. Protozoa and helminths are found to induce different immune responses, and protozoa and helminths co-infections may affect host immune response to these parasites and the outcomes of infections. Toxoplasma gondii is a neurotropic protozoan parasite causing persistent subclinical neuroinflammations, which is associated with psychiatric and neurodegenerative diseases, as well as other diseases. However, there has been limited knowledge on the mechanisms underlying the interaction of T. gondii and nematodes co-infections until now. This review provides an overview of the interactions and regulatory mechanisms of T. gondii co-infections with Toxocara spp., Trichinella spiralis, Heligmosomoides spp. and Nippostrongylus brasiliensis in human or animal hosts.

Key words： Toxoplasma gondii; Nematodes; Co-infection; Interaction; Mechanism

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