收稿日期: 2024-12-25
修回日期: 2025-02-10
网络出版日期: 2025-05-27
基金资助
国家自然科学基金(32172882)
Progress of researches on the structure and biological functions of protein disulfide isomerase in apicomplexan protozoa
Received date: 2024-12-25
Revised date: 2025-02-10
Online published: 2025-05-27
Supported by
National Natural Science Foundation of China(32172882)
王璐阳 , 张乾 , 张素梅 , 张龙现 . 顶复门原虫蛋白质二硫键异构酶研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2025 , 43(3) : 423 -428 . DOI: 10.12140/j.issn.1000-7423.2025.03.018
Apicomplexan protozoa are a class of obligate intracellular parasites, and most of them are pathogens of zoonoses, with a wide range of hosts, causing huge economic losses to the livestock breeding industry and posing great threats to public health security. It has been demonstrated that protein disulfide isomerase (PDI) is widely present in apicomplexan protozoa, which is mainly associated with the invasion, adhesion and cellular immunity of parasites and plays an important role in the growth and development process of parasites. This review summarizes the advances in the structure and biological functions of PDI in apicomplexan protozoa, so as to provide insights into management of parasitic diseases and research and development of vaccines against parasitic diseases.
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