收稿日期: 2024-09-13
修回日期: 2024-11-27
网络出版日期: 2025-06-18
基金资助
国家自然科学基金(31960707);国家自然科学基金(32160842);国家自然科学基金(32460893);内蒙古自治区科技计划(2022YFDZ0049);内蒙古自治区直属高校基本科研业务费(GXKY22042);云南省建设面向南亚东南亚科技创新中心专项-云南省兽用药品国际联合研发中心(202403AP140012)
Research progress on calreticulin in parasitic helminths and its role in immunity
Received date: 2024-09-13
Revised date: 2024-11-27
Online published: 2025-06-18
Supported by
National Natural Science Foundation of China(31960707);National Natural Science Foundation of China(32160842);National Natural Science Foundation of China(32460893);Inner Mongolia Autonomous Region Science and Technology Program(2022YFDZ0049);Basic scientific research funds for universities directly under the Inner Mongolia Autonomous Region(GXKY22042);Yunnan Province Special Project for Building a Science and Technology Innovation Center for South and Southeast Asia-Yunnan Province International Joint Research and Development Center for Veterinary Pharmaceuticals(202403AP140012)
赵昱源 , 王思睿 , 王梦奇 , 段蕊 , 何沛霞 , 孙树民 . 寄生性蠕虫钙网蛋白及其在免疫中作用的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2025 , 43(3) : 416 -422 . DOI: 10.12140/j.issn.1000-7423.2025.03.017
Calreticulin is a soluble Ca2+-binding protein that is mainly present endoplasmic reticulum, which has a variety of biological functions, such as Ca2+ signal transduction, protein folding, and antigen presentation. The calreticulin of parasitic helminths is secreted by the worm body or expressed on the surface of the worm body, which plays an important role in the parasite motility, growth and development. In addition, the calreticulin of some helminths is strongly associated with its immune evasion process. This review summarizes the structure composition and function of calreticulin, and discusses the mechanisms underlying the regulation of host Th1/Th2 immune responses and the regulatory mechanisms of host immune cells, immune molecules and complement system by calreticulin, so as to provide new insights into management of helminthiasis.
Key words： Parasitic helminth; Calreticulin; Immune response; Immune evasion
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