收稿日期: 2024-10-19
修回日期: 2024-12-01
网络出版日期: 2025-03-26
基金资助
天山英才项目(2023TSYCQNTJ0045);新疆维吾尔自治区重点研发项目(2022B03013-3)
Research progress on Toll-like receptors-mediated host immune responses in echinococcosis
Received date: 2024-10-19
Revised date: 2024-12-01
Online published: 2025-03-26
Supported by
Tianshan Young Talents Project(2023TSYCQNTJ0045);Key Research and Development Project of Xinjiang Uygur Autonomous Region(2022B03013-3)
周檀芳 , 朱江 , 徐心路 , 祖力皮喀尔·图孙尼亚孜 , 卡力比夏提·艾木拉江 , 温浩 . Toll样受体介导的宿主免疫应答在棘球蚴病中的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2025 , 43(1) : 124 -128 . DOI: 10.12140/j.issn.1000-7423.2025.01.019
Echinococcosis is a zoonotic parasitic disease caused by the larval stage of Echinococcus species. Echinococcus infection may modulate host immune response and alter host immune microenvironments, thereby triggering immune and inflammatory responses. As a pattern recognition receptor, Toll-like receptors (TLRs) may effectively recognize pathogen-associated molecular patterns and activate downstream signaling pathways by regulating TLR expression and functions, which play an important role in host immune responses to echinococcosis. This review summarizes the latest progress of TLRs in echinococcosis research, with a special emphasis on TLR2 and TLR4, and discusses their potential applications in future treatments of echinococcosis, so as to provide new insights into for echinococcosis prevention and treatment.
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