目的 分析甘肃省棘球蚴病患者手术前后生命质量的变化，评价手术治疗措施对患者生命质量的影响。方法 调查甘肃省中央转移支付地方棘球蚴病防治项目县中纳入项目管理并进行手术的棘球蚴病患者，采用调查问卷和EQ-5D-5L量表收集患者基本情况、首诊情况、手术情况和手术前后的生命质量情况。用SPSS 19.0、Origin 2021软件对数据进行统计学分析。结果 共收集病例856例，其中男性417例，女性439例。年龄最小为7岁，最大为85岁，平均为53岁。CE患者737例，AE患者14例，未分型患者105例。棘球蚴病患者首次手术术后时间最长的为17.5年，最短的为1个月；调查时间与首次手术时间的平均时间间隔为7.4年（89个月）。棘球蚴病患者手术前后的健康效用值分别为0.910 ± 0.142和0.967 ± 0.067，术后较术前提高了6.3%（Z = -12.081，P < 0.05）；患者手术前后的视觉模拟标尺（VAS）评分分别为（79.10 ± 16.00）和（86.25 ± 11.64）分，术后较术前提高了9.0%（Z = -15.292，P < 0.05）。棘球蚴病患者的健康效用值差值和VAS评分差值的取值范围分别为[-0.308，1.348]和[-55，90]。42.8%（366/856）的棘球蚴病患者手术后健康效用值增加，62.7%（537/856）的患者手术后VAS评分增加。五维度困难程度减轻的占19.1%（818/4 280）；困难程度不变的占76.5%（3 275/4 280），整体健康状况不变组患者的术前健康效用值和VAS评分均高于其他组（Z = -16.580、-8.606，P < 0.05）；困难程度加重的占4.4%（187/4 280），健康效用值下降组患者的首次手术年龄高于其他组（Z = 4.393，P < 0.05）；VAS评分下降组患者的首次手术年龄高于其他组（Z = 3.154，P < 0.05）。趋势性检验结果显示，患者的健康效用值（F = 12.957，P_trend < 0.05）和VAS评分（F = 10.808，P_trend < 0.05）均与术后呈线性正相关趋势。结论 手术治疗措施可改善棘球蚴病患者的生命质量。

Objective To analyse the changes in quality of life of patients with echinococcosis in Gansu Province pre- and post-surgery, and evaluate the impact of surgical treatments on the patients’ quality of life. Methods The patients with echinococcosis underwent surgery and were managed under the National Project for Echinococcosis Control and Prevention in Gansu Province were surveyed using questionnaire and EQ-5D-5L questionnaire to collect basic information, first visit record, surgical performance, and the quality of life pre- and post-surgery. The data were analyzed by SPSS 19.0 and Origin 2021. Results A total of 856 cases collected, including 417 males and 439 females. The age ranges from 7 to 85 years, with an average of 53 years. There were 737 cases of CE patients, 14 cases of AE patients, and 105 cases of unclassified patients. The longest time from the first surgery to postoperative follow-up for patients with echinococcosis was 17.5 years, and the shortest was 1 month. The average time interval between the investigation and the first surgery was 7.4 years (89 months). The preoperative and postoperative health utility values for patients with echinococcosis were 0.910 ± 0.142 and 0.967 ± 0.067, respectively, showing a 6.3% improvement postsurgery (Z = -12.081, P < 0.05). The preoperative and postoperative visual analog scale (VAS) scores were 79.10 ± 16.00 and 86.25 ± 11.64, respectively, showing a 9.0% improvement postsurgery (Z = -15.292, P < 0.05). The health utility value difference in patients with echinococcosis ranged between -0.308 and 1.348, the VAS score difference ranged between -55 and 90. A total of 42.8% (366/856) patients had an increase in health utility value postsurgery, and 62.7% (537/856) of patients had an increase in VAS score postsurgery. The proportion of patients with reduction of difficulties in the five dimensions was 19.1% (818/4 280), unchanged was 76.5% (3 275/4 280), and those with stable overall health had higher health utility values (Z = -16.580, P < 0.05) and VAS scores (Z = -8.606, P < 0.05). The proportion of patients with increased difficulties was 4.4% (187/4 280), the average age of first operation in the group with decreased health utility value was higher than that in another group (Z = 4.393, P < 0.05). The average age of first operation in the group with decreased VAS score was higher than that in another group (Z = 3.154, P < 0.05). The patients’ health utility value (F = 12.957, P_trend < 0.05) and VAS score (F = 10.808, P_trend < 0.05) showed a trend of positive linear correlation with the extension of postsurgery time. Conclusion Surgical treatment could impact the quality of life for patients with echinococcosis.