收稿日期: 2023-06-01
修回日期: 2023-07-20
网络出版日期: 2024-03-12
基金资助
国家自然科学基金(81971961)
Research progress on Plasmodium membrane protein complexes
Received date: 2023-06-01
Revised date: 2023-07-20
Online published: 2024-03-12
Supported by
National Natural Science Foundation of China(81971961)
韩竹茜 , 朱晓彤 . 疟原虫内膜复合体蛋白研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2024 , 42(1) : 111 -116 . DOI: 10.12140/j.issn.1000-7423.2024.01.016
Malaria is one of the world’s three most serious infectious diseases which caused by Plasmodium spp. The Plasmodium merozoite, ookinete, and sporozoite all have characteristic endomembrane complexes (IMCs). IMC is localized under the plasma membrane and is closely linked to the subpellicular protein network on the cytoplasmic side of the membrane. IMC is involved in the parasite development and invasion of the host cells by providing a support backbone during cell division, maintaining cell morphology and stability. In-depth studies of the structure, function and transcriptional regulation mechanism of IMC protein are of great significance for the development of corresponding inhibitors or blockers to block malaria transmission. In this paper, we reviewed the research progress of IMC protein structure and transcriptional regulation mechanisms in recent years.
Key words： Plasmodium; Inner membrane complex; Alveolins; Palmitoylation; Phosphorylation
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