收稿日期: 2023-09-22
修回日期: 2023-11-03
网络出版日期: 2024-03-12
基金资助
国家重点研发计划(2021YFC2300800);国家重点研发计划(2021YFC2300804)
Progress of echinococcosis control in China, 2022
Received date: 2023-09-22
Revised date: 2023-11-03
Online published: 2024-03-12
Supported by
National Key Research and Development Program of China(2021YFC2300800);National Key Research and Development Program of China(2021YFC2300804)
为掌握全国棘球蚴病防治进展,总结防治经验,发现存在的问题,对2022年全国棘球蚴病防治工作数据进行描述性分析。截至2022年底,全国共有370个棘球蚴病流行县(市、区、旗)29 926个流行村。2022年全国流行县(市、区、旗)现有棘球蚴病患者25 227例,平均患病率为58.35/10万(25 227/43 232 609)。细粒棘球蚴病15 554例,多房棘球蚴病8 169例,混合感染255例,未分型1 249例。新发现棘球蚴病患者1 270例,其中细粒棘球蚴病991例,多房棘球蚴病89例,混合感染5例,未分型185例;< 12岁人群102例,≥ 12岁人群1 168例。2022年,全国棘球蚴病流行省(自治区)共开展人群腹部超声筛查3 576 121人次,其中,< 12岁人群筛查751 440人次,≥ 12岁人群筛查2 824 681人次;血清学检测超声筛查疑似人员17 404人次。2022年370个监测点< 12岁人群超声筛查患病率为0.02%(60/287 437),其中新发现患者占患者数的40.00%(24/60)。Ⅰ、Ⅱ类流行县(市、区、旗)监测点≥ 12岁人群超声筛查患病率为0.29%(772/270 407),新发现患者占患者数的8.29%(64/772)。2022年开展药物治疗18 354人,肝肾功能检查及不良反应处置16 625人,手术治疗1 418人[细粒棘球蚴病患者占69.82%(990/1 418),多房棘球蚴病患者占26.52%(376/1 418)]。2022年随访结果显示,治愈999例,治疗有效20 599例,治疗无效2 546例,死亡(非棘球蚴病死因)374例,排除239例,失访372例,未到随访时间884例,病例外迁他地170例。2022年全国流行乡(镇)共有犬2 478 608条,其中登记管理的犬2 250 694条。共34 646个村开展了犬驱虫工作,药物驱虫犬次数24 289 457次。野外犬科动物驱虫投药119 473份。采集并检测家犬粪样394 851份,粪棘球绦虫抗原阳性1 756份,阳性率为0.44%。采集并检测野外犬科动物粪样62 884份,粪棘球绦虫抗原阳性1 201份,阳性率为1.91%。2022年抽查屠宰的家畜117 303头,患病率为0.88%(1 038/117 303)。检查野外啮齿类动物43 705只,患病率为0.92%(403/43 705)。2022年我国棘球蚴病流行态势得到基本控制,但防治工作还存在诸多困难和挑战,需要继续加强棘球蚴病防治工作力度,提高群众的防病意识;完善疾病监测体系,发挥区域联防联控机制作用,全面落实各项综合防治措施。
蒉嫣 , 薛垂召 , 王旭 , 刘白雪 , 王莹 , 王立英 , 杨诗杰 , 韩帅 , 许学年 . 2022年全国棘球蚴病防治工作进展[J]. 中国寄生虫学与寄生虫病杂志, 2024 , 42(1) : 8 -16 . DOI: 10.12140/j.issn.1000-7423.2024.01.002
To understand the work progress in nationwide control of echinococcosis, we summarize the experience and find the existing problems through descriptive analysis on the national control data in 2022. As of the end of 2022, there were 370 echinococcosis endemic counties (city, district, banner) covering 29 926 villages in China, having a total of 25 227 echinococcosis cases with an average prevalence of 58.35 per 100 000 (25 227/43 232 609), among them, 15 554 cases were of cystic echinococcosis, 8 169 cases alveolar echinococcosis, 255 mixed infection, and 1 249 cases pending; 1 270 cases were newly found, including 991 cases of cystic echinococcosis, 89 alveolar echinococcosis, 5 mixed infection, and 185 pending; revealing 102 cases were at age < 12, and 1 168 case were of age ≥ 12. In 2022, population screening by abdominal ultrasound scanning was performed in all endemic provinces (autonomous regions) for 3 576 121 person/times. Of them, 751 440 person/examinations were performed for the residents younger than 12, and 2 824 681 person/times were performed for residents older than 12. The serological examination was carried out for the suspected individuals for 17 404 person/times. According to data from 370 surveillance sites in 2022, the prevalence in residents younger than 12 was 0.02% (60/287 437) by ultrasound screening, with 40.00% (24/60) newly diagnosed cases. The prevalence in the residents older than 12 was 0.29% (772/270 407) in type Ⅰ and type Ⅱ endemic counties (city, district, banner). The newly diagnosed cases accounted for 8.29% (64/772) of the detected patients. In 2022, 18 354 patients received drug treatment, of which 16 625 patients received liver and kidney function tests or management against adverse reactions. A total of 1 418 patients received surgical treatment, including 69.82% (990/1 418) for cystic echinococcosis, and 26.52% (376/1 418) for alveolar echinococcosis. In 2022, the follow-up results showed that 999 cases were cured, 20 599 cases responded to the treatment, 2 546 cases failed in the treatment, 374 cases died (the causes of the deaths were not echinococcosis), 239 cases were excluded, 372 cases were lost in follow-up, 884 cases had not completed the follow-up, and 170 cases migrated to other places. In 2022, there were 2 478 608 dogs in the endemic townships (towns) nationwide, of which 2 250 694 were registered for management. Deworming work was conducted for dogs in 34 646 villages, with 24 289 457 deworming times. Wild canines were demormed by delivering 119 473 drug doses. A total of 394 851 fecal samples from domestic dogs were collected and detecteded, of which 1 756 were found positive for Echinococcus coproantigen, with a positive rate of 0.44% (1 756/394 851). Of the wild canines, 62 884 field fecal samples were collected and detected, among which 1 201 were found positive for Echinococcus coproantigen, with a positive rate of 1.91% (1 201/62 884). A total of 117 303 slaughtered livestock were randomly examined, among which 1 038 were diseased, with a prevalence of 0.88%. A total of 43 705 field rodents were examined, among which 403 were diseased, with a prevalence of 0.92%. Although the endemic of echinococcosis in China has been essentially controlled, there remain many difficulties and challenges in control work. It is imperative to continuously strengthen the prevention and control measures for echinococcosis, raise the disease prevention awareness, explore optimizing the control strategy, exert the role of regional joint prevention and control mechanisms and fully implement comprehensive measures to further control the prevalence of echinococcosis.
Key words: Echinococcosis; Cystic echinococcosis; Alveolar echinococcosis; Epidemiology; China
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