收稿日期: 2023-01-14
修回日期: 2023-03-30
网络出版日期: 2023-11-06
Damage caused by chronic infection of Toxoplasma gondii on the host central nervous system and its mechanism
Received date: 2023-01-14
Revised date: 2023-03-30
Online published: 2023-11-06
薛羽珊 , 林萍 , 程训佳 , 冯萌 . 慢性弓形虫感染对宿主中枢神经系统的损伤及其作用机制[J]. 中国寄生虫学与寄生虫病杂志, 2023 , 41(5) : 527 -531 . DOI: 10.12140/j.issn.1000-7423.2023.05.001
Toxoplasma gondii is an obligate intracellular parasite that widely distributes in the world and causes zoonotic toxoplasmosis. In recent years, parasite infection in the brain has been paid more and more attention. T. gondii can cause central nervous system damage, often manifested as depression, schizophrenia, epilepsy and other symptoms. In this paper, the process and mechanism of T. gondii establishing chronic infection through blood-brain barrier, causing central nervous system injury and disease are reviewed.
Key words： Toxoplasma gondii; Central nervous system; Chronic infection
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