目的 总结并分析双叶槽绦虫肠道感染病例的临床表现及实验室指标变化特征。 方法 收集2009年1月—2022年7月在北京友谊医院确诊的18例双叶槽绦虫感染病例的病历资料，包括性别、年龄、流行病学史（居住地、国外旅居史及饮食习惯）、临床表现、入院期间血常规、肝功能、粪便虫卵检测和虫种鉴定、治疗和预后等，对双叶槽绦虫感染的临床特点进行总结，并分析比较其实验室指标差异。 结果 18例感染病例中男性、女性各9例，平均年龄为（28.88 ± 11.57）岁，年龄最小为8岁，最大为47岁。流行病学调查结果显示，其中12例为北京本地病例，6例来自其他省份；7例有国外旅居史；所有病例均有食生/半生鱼肉或牛肉史。确诊的18例双叶槽绦虫感染病例临床表现为腹痛、腹胀症状6例，头晕2例，肛周瘙痒、体质量下降均未见，无症状10例。炎性指标白细胞、C-反应蛋白及血沉均未见异常，贫血指标红细胞和血红蛋白未见降低，嗜酸粒细胞未见升高。肝功能指标均未见升高。粪检查见双叶槽绦虫虫卵8例，所有病例粪样中均可见到节片。给予中药槟榔-南瓜子疗法进行驱虫治疗，均治愈。 结论 双叶槽绦虫感染病例多无临床症状或轻微的消化道症状，血常规及肝功能检测均未见明显异常，可结合粪检等病原学检查和流行病学调查进行早期诊断。

Objective To summarize and analyze the characteristics of clinical manifestation and laboratory indicators of patients with intestinal infection of Diphyllobothrium tapeworm. Methods The medical record, including gender, age, epidemiological history (residence, history of overseas traveling and dietary habits), clinical manifestation, laboratory examinations when admitted (blood routing test, liver function, fecal examination for parasite eggs, and parasite species identification), treatment record and prognosis were collected from 18 diphyllobothriasis cases diagnosed at the Beijing Friendship Hospital, Capital Medical University from January 2009 to July 2022. Information on patients' clinical features and the changes in laboratory findings were summarized and analyzed. Results The 18 cases included 9 male and 9 female respectively, of them the age ranged from 8 to 47 years with an average of (28.88 ± 11.57) years. Epidemiological inquiry indicated that 12 cases were locals from Beijing, while 6 patients were from other provinces, among them 7 patients had overseas traveling history, and all patients had history of consuming raw/undercooked fish meat and beef. The clinical manifestation of the 18 cases were abdominal pain and distension in 6 cases, and dizziness in 2 cases, whereas anal pruritus and body weight loss were not seen, and 10 were asymptomatic. The inflammatory indicator of leukocyte count, C-reactive protein, erythrocyte sedimentation rate, anemia indicator of erythrocyte and hemoglobin, eosinophils count, and liver function showed no abnormal changes. Fecal examination found Diphyllobothrium tapeworm eggs in the samples from 8 cases, and proglottids from all cases. Deworming regime with Chinese medicine areca-pumpkin seed cured all patients. Conclusion Most of the cases infected with Diphyllobothrium tapeworm are asymptomatic or showed only mild gastrointestinal symptoms, with no significant abnormal changes in blood routine test and liver function examination. Early diagnosis could be made by fecal examination etiologically and epidemiological inquiry.