收稿日期: 2022-07-25
修回日期: 2022-09-16
网络出版日期: 2023-04-07
基金资助
国家自然科学基金(NSF-81971486);国家自然科学基金(82272362)
Research advances on the role and mechanism of neutrophil extracellular traps in parasitic infection
Received date: 2022-07-25
Revised date: 2022-09-16
Online published: 2023-04-07
Supported by
National Natural Science Foundation of China(NSF-81971486);National Natural Science Foundation of China(82272362)
中性粒细胞胞外诱捕网（NET）是中性粒细胞胞内染色质与颗粒蛋白结合后释放至胞外所形成的网状结构。研究表明，原虫和蠕虫等寄生虫感染可诱导NET形成，并在抗寄生虫的免疫防御与寄生虫感染引起的免疫病理中发挥重要作用。本文综述了NET在常见原虫和蠕虫感染中的形成机制及其作用的最新研究进展，旨在为寄生虫病预防与治疗提供新思路。
关键词： 中性粒细胞; 中性粒细胞胞外诱捕网; 原虫感染; 蠕虫感染
黎嫦 , 杜新月 , 严敏 , 王兆军 . 中性粒细胞胞外诱捕网在寄生虫感染中的作用和机制研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2023 , 41(2) : 219 -222 . DOI: 10.12140/j.issn.1000-7423.2023.02.015
Neutrophil extracellular traps (NETs) are neutrophil-derived extracellular net-like structures that are composed of chromatin and granule proteins. Initial reports demonstrated that the infection of parasites like protozoa and helminths could induce NETs formation, which plays important roles in the immune defence against parasites and immunopathology caused by infection. This review described the mechanisms of NETs formation and the role of NETs in protozoan and helminth infection, which provides new ideas for the prevention and treatment of parasitic diseases.
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