收稿日期: 2022-09-19
修回日期: 2022-11-03
网络出版日期: 2023-04-23
基金资助
上海市教育委员会科研创新计划(201901070007E00017)
The biological significance of malarial hemozoin’s formation
Received date: 2022-09-19
Revised date: 2022-11-03
Online published: 2023-04-23
Supported by
Innovation Program of Shanghai Municipal Education Commission(201901070007E00017)
孙军 . 疟原虫色素形成的生物学意义[J]. 中国寄生虫学与寄生虫病杂志, 2023 , 41(2) : 209 -212 . DOI: 10.12140/j.issn.1000-7423.2023.02.013
The formation of the Plasmodium hemozoin and its biological significance has been controversial. Given that it is closely related to the growth, reproduction and pathogenicity of Plasmodium, the biological function of malarial hemozoin needs to be further elucidated. This article preliminarily discussed the morphology of hemozoin, the formation of hemozoin, the biological function of hemozoin, its relationship with the host macrophages, and its pathogenicity to reveal the role of the formation of hemozoin in the use of heme and iron, the unique function of hemozoin in the evolution, growth, and reproduction of malaria parasites, which helps to clarify the limitations of the traditional understanding of the Plasmodium hemozoin formation. It provides ideas for further understanding the pathogenic mechanism of Plasmodium and developing new antimalarial drugs.
Key words： Plasmodium; Malarial hemozoin; Heme; Iron
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