收稿日期: 2021-12-21
修回日期: 2022-02-11
网络出版日期: 2022-08-19
基金资助
国家公益性卫生行业科研专项(201502021)
Analysis on the prevalence of Clonorchis sinensis infection in Lingshan County, Guangxi from 2016 to 2019
Received date: 2021-12-21
Revised date: 2022-02-11
Online published: 2022-08-19
Supported by
Public Health Project of the National Health and Family Planning Commission of the People’s Republic of China(201502021)
为了解广西壮族自治区（简称广西）灵山县人群华支睾吸虫感染情况,2016—2019年在灵山县东、西、南、北、中等5个片区各随机抽取1个乡（镇）的1个行政村开展调查,每个行政村整群抽样法抽取≥ 3岁的常住居民200人。每年共调查1 000人以上,往年已参加过调查的人不再纳入。采集调查对象粪样,用改良加藤厚涂片法（Kato-Katz 法,一粪二检）检查华支睾吸虫虫卵并计数。结果显示,2016—2019年灵山县共调查4 363人,华支睾吸虫总感染率为4.86%（212/4 363）,以轻度感染为主,占总感染数的93.87%（199/212）,无重度感染者。2016—2019年感染率分别为3.59%（42/1 170）、5.03%（51/1 014）、7.58%（79/1 042）和3.52%（40/1 137）,不同年度间感染率差异有统计学意义（χ2 = 25.271,P < 0.01）。5个调查点中,感染率最高的为烟墩镇长麓村（13.12%,124/945）,最低的为那隆镇陈垌村（0.37%,3/821）,不同调查点人群感染率间差异有统计学意义（χ2 = 211.912,P < 0.01）。男性感染率为7.43%（167/2 248）,高于女性的2.13%（45/2 115）（χ2 = 66.244,P < 0.01）;50~59岁年龄组感染率最高（10.4%,62/596）,各年龄组感染率差异有统计学意义（χ2 = 142.690,P < 0.01）;教师及其他职业感染率最高（9.33%,7/75）,不同职业中人群感染率差异有统计学意义（χ2 = 81.314,P < 0.01）;大专及以上文化水平人群感染率最高（8.00%,2/25）,不同文化水平人群间感染率差异有统计学意义（χ2 = 40.237,P < 0.01）。2016—2019年广西灵山县华支睾吸虫感染处于中度流行水平,各乡（镇）的感染率存在差异。
黄光华 , 张波 , 赖海涛 , 吕国丽 , 林源 , 唐雯茜 , 万孝玲 , 蒋智华 , 刘健 . 2016—2019年广西灵山县人群华支睾吸虫感染情况分析[J]. 中国寄生虫学与寄生虫病杂志, 2022 , 40(5) : 673 -676 . DOI: 10.12140/j.issn.1000-7423.2022.05.017
To understand the prevalence of Clonorchis sinensis infection in Lingshan County, one town/village was randomly selected from each of the eastern, western, southern, northern and central administrative regions for investigation from 2016 to 2019. By cluster sampling, 200 permanent residents aged more than 3 years were selected from each study site. More than 1 000 people were surveyed each year with no duplicate enrollment. The fecal samples were collected, and processed using the modified Kato-Katz method (two examinations per sample) for egg counts. Among 4 363 participants, 4.86% (212/4 363) were infected with C. sinensisand the majority were mild infections, accounting for 93.87% (199/212) of the total infections with no severe infection case. The infection rates from 2016 to 2019 were 3.59% (42/1 170), 5.03% (51/1 014), 7.58% (79/1 042) and 3.52% (40/1 137), respectively. The difference between years was statistically significant (χ2 = 25.271, P < 0.01). Among the five survey sites, the highest infection rate was found in Changlu Village, Yandun Town (13.12%, 124/945), and the lowest was found in Chentong Village, Nalong Town (0.37%, 3/821). The difference between study sites was statistically significant (χ2 = 211.912, P < 0.01). The infection rate in males was 7.43% (167/2 248), which was significantly higher than that in females (2.13%, 45/2 115) (χ2 = 66.244, P < 0.01). The 50-59 age group had the highest infection rate (10.4%, 62/596) and the differences between age groups were significant (χ2 = 142.690, P < 0.01). The infection rate of teachers and other occupations was the highest (9.33%, 7/75), and the differences between occupations were significant (χ2 = 81.314, P < 0.01). The highest infection rate found in those with college or higher education levels (8.00%, 2/25), and significant difference in people with different education levels (χ2 = 40.237, P < 0.01). From 2016 to 2019, the prevalence of C. sinensis in Lingshan County was moderate and different for each town/village.
Key words： Clonorchis sinensis; Infection rate; Lingshan County
| [1] | WHO. Working to overcome the global impact of neglected tropical diseases: first WHO report on neglected tropical diseases[R]. Geneva: WHO, 2010: 39-137. |
| [2] | Qian MB,, Chen YD,, Liang S, et al. The global epidemiology of clonorchiasis and its relation with cholangiocarcinoma[J]. Infect Dis Poverty, 2012, 1: 4. |
| [3] | Qian MB,, Zhou XN. Clonorchis sinensis[J]. Trends Parasitol, 2021, 37(11): 1014-1015. |
| [4] | Bouvard V,, Baan R,, Straif K, et al. A review of human carcinogens: Part B: biological agents[J]. Lancet Oncol, 2009, 10(4): 321, 322. |
| [5] | Yang YC,, Li XM,, Xu HB, et al. Survey on current status of important human parasitic diseases in Guangxi, China[J]. J Pathog Biol, 2007, 2(5): 368-370, 359. (in Chinese) |
| [5] | 杨益超,, 黎学铭,, 许洪波, 等. 广西人体重要寄生虫病现状调查[J]. 中国病原生物学杂志, 2007, 2(5): 368-370, 359.) |
| [6] | Chen YD,, Zhou CH,, Zhu HH, et al. National survey on the current status of important human parasitic diseases in China in 2015[J]. Chin J Parasitol Parasit Dis, 2020, 38(1): 5-16.(in Chinese) |
| [6] | ( 陈颖丹,, 周长海,, 朱慧慧, 等. 2015年全国人体重点寄生虫病现状调查分析[J]. 中国寄生虫学与寄生虫病杂志, 2020, 38(1): 5-16.) |
| [7] | Jiang ZH,, Wan XL,, Lv GL, et al. High prevalence of Clonorchis sinensis infection in Guangxi, Southern China[J]. Trop Med Health, 2021, 49(1): 1-11. |
| [8] | Nationl Health Commission of the People’s Republic of China. Detection of intestinal helminthes- -the Kato-Katz method: WS/T 570—2017[S]. Beijing: Standards Press of China, 2017. (in Chinese) |
| [8] | ( 中华人民共和国国家卫生和计划生育委员会. 肠道蠕虫检测改良加藤厚涂片法: WS/T 570—2017[S]. 北京: 中国标准出版社, 2017.) |
| [9] | Wan XL,, Zhang WW,, Jiang ZH, et al. Investigation on the status of human important parasitic disease in Guangxi in 2015[J]. Chin Trop Med, 2019, 19(1): 19-22, 30. (in Chinese) |
| [9] | ( 万孝玲,, 张伟尉,, 蒋智华, 等. 广西2015年人体重点寄生虫感染现状调查[J]. 中国热带医学, 2019, 19(1): 19-22, 30.) |
| [10] | Xu LQ,, Jiang ZX,, Yu SH, et al. Nationwide survey of the distribution of human parasites in china: infection with parasite species in human population[J]. Chin J Parasitol Parasit Dis, 1995, 13(1): 3-9. (in Chinese) |
| [10] | ( 许隆祺,, 蒋则孝,, 余森海, 等. 全国人体寄生虫分布调查: 虫种的人群感染[J]. 中国寄生虫学与寄生虫病杂志, 1995, 13(1): 3-9.) |
| [11] | Chen XB,, Wu GL,, Sun X, et al. Modern parasitology[M]. Beijing: People’s Military Medical Publisher, 2002: 571. (in Chinese) |
| [11] | ( 陈兴保,, 吴观陵,, 孙新, 等. 现代寄生虫病学[M]. 北京: 人民军医出版社, 2002: 571.) |
| [12] | Jiang ZH,, Yang YC,, Wan XL, et al. Preliminary analysis of geographical and basin distribution characteristics of clonorchiasis sinensis in Guangxi[J]. Chin Trop Med, 2015, 15(9): 1057-1061. (in Chinese) |
| [12] | ( 蒋智华,, 杨益超,, 万孝玲, 等. 广西华支睾吸虫病地理和流域分布特点的初步分析[J]. 中国热带医学, 2015, 15(9): 1057-1061.) |
| [13] | Chen HS,, Lyu GL,, Lu ZB, et al. Investigation on prevalence of soil-transmitted nematodes and Clonorchis sinensis in four counties of eastern Guangxi from 2015 to 2016[J]. Appl Prev Med, 2021, 27(2): 93-96, 101. (in Chinese) |
| [13] | 陈洪森,, 吕国丽,, 陆正斌, 等. 2015—2016年广西东部四县(市)土源性线虫和华支睾吸虫人群感染调查[J]. 应用预防医学, 2021, 27(2): 93-96, 101.) |
| [14] | Huang Y,, Zhang GH,, Liang MQ, et al. Analysis on the infection status of Clonorchis sinensis among the population in Wuming County, Guangxi[J]. Appl Prev Med, 2021, 27(3): 197-200. (in Chinese) |
| [14] | ( 黄勇,, 张国汉,, 梁美群, 等. 广西武鸣县人群华支睾吸虫感染情况分析[J]. 应用预防医学, 2021, 27(3): 197-200.) |
| [15] | Yang JX,, Yang XA,, Wan XL, et al. Status of Clonorchis sinensis in the minority area of northern Guangxi, 2017[J]. Chin Trop Med, 2019, 19(6): 571-573. (in Chinese) |
| [15] | ( 杨进新,, 杨杏爱,, 万孝玲, 等. 广西桂北少数民族地区2017年华支睾吸虫感染调查[J]. 中国热带医学, 2019, 19(6): 571-573.) |
| [16] | Lü GL,, Wan XL,, Liu J, et al. Analysis on clonorchiasis surveillance in Guangxi Zhuang Autonomous Region from 2016 to 2020[J]. J Trop Dis Parasitol, 2021, 19(3): 121-126. (in Chinese) |
| [16] | ( 吕国丽,, 万孝玲,, 刘健, 等. 2016—2020年广西壮族自治区华支睾吸虫病监测结果分析[J]. 热带病与寄生虫学, 2021, 19(3): 121-126.) |
/
| 〈 |
|
〉 |