收稿日期: 2022-03-22
修回日期: 2022-05-09
网络出版日期: 2022-10-14
基金资助
国家自然科学基金(82072307);国家自然科学基金(81772224)
Research progress on liver fibrosis caused by Echinococcus infection
Received date: 2022-03-22
Revised date: 2022-05-09
Online published: 2022-10-14
Supported by
National Natural Science Foundation of China(82072307);National Natural Science Foundation of China(81772224)
蒋小凤 , 沈玉娟 . 棘球蚴感染致肝纤维化的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2022 , 40(5) : 656 -660 . DOI: 10.12140/j.issn.1000-7423.2022.05.014
Echinococcus infection may cause damage to hepatocytes. Hepatic fibrosis is a process of excessive proliferation of connective tissue after liver injury. In the dynamic process of liver self-healing, the activation of hepatic stellate cells, the increased extracellular matrix production and the decreased extracellular matrix consumption result in fibrosis. This review summarizes the regulatory mechanisms of hepatic stellate cells, cytokines and microRNA involved in hepatic fibrosis caused by Echinococcus infection.
Key words： Echinococcus; Hepatic fibrosis; Cytokines; MicroRNA
| [1] | Parola M,, Pinzani M. Liver fibrosis: pathophysiology, pathogenetic targets and clinical issues[J]. Mol Aspects Med, 2019, 65: 37-55. |
| [2] | Niu FQ,, Chong SG,, Qin MQ, et al. Mechanism of fibrosis induced by Echinococcus spp.[J]. Diseases, 2019, 7(3): 51. |
| [3] | Tsuchida T,, Friedman SL. Mechanisms of hepatic stellate cell activation[J]. Nat Rev Gastroenterol Hepatol, 2017, 14(7):397-411. |
| [4] | Rygiel KA,, Robertson H,, Marshall HL, et al. Epithelial-mesenchymal transition contributes to portal tract fibrogenesis during human chronic liver disease[J]. Lab Investig, 2008, 88(2): 112-123. |
| [5] | Friedman SL. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver[J]. Physiol Rev, 2008, 88(1): 125-172. |
| [6] | Kisseleva T,, Cong M,, Paik Y, et al. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis[J]. Proc Natl Acad Sci USA, 2012, 109(24): 9448-9453. |
| [7] | Zhang DY,, Goossens N,, Guo JS, et al. A hepatic stellate cell gene expression signature associated with outcomes in hepatitis C cirrhosis and hepatocellular carcinoma after curative resection[J]. Gut, 2016, 65(10): 1754-1764. |
| [8] | Puche JE,, Saiman Y,, Friedman SL. Hepatic stellate cells and liver fibrosis[J]. Compr Physiol, 2013, 3(4): 1473-1492. |
| [9] | Li TX,, Shi ZD,, Rockey DC. Preproendothelin-1 expression is negatively regulated by IFN-γ during hepatic stellate cell activation[J]. Am J Physiol Gastrointest Liver Physiol, 2012, 302(9): G948-G957. |
| [10] | Shi ML. Effects of Echinococcus multilocularis cyst fluid on prolifcration and apoptosis of rat hepatic stellate cell[D]. Xining: Qinghai University, 2014: 46. (in Chinese) |
| [10] | ( 石明亮. 泡球蚴囊液对大鼠肝星状细胞增殖和凋亡影响[D]. 西宁: 青海大学, 2014: 46.) |
| [11] | Ren L,, Wang ZX,, Liu ZS, et al. Effect of Echinococcus cyst fluid on proliferation and cell cycle progression of rat hepatic stellate cell[J]. Chin J Bases Clin Gen Surg, 2016, 23(5): 517-520. (in Chinese) |
| [11] | ( 任利,, 王志鑫,, 刘志胜, 等. 泡球蚴囊液对大鼠肝脏星状细胞增殖的影响[J]. 中国普外基础与临床杂志, 2016, 23(5): 517-520.) |
| [12] | Wang LM. Crosstalk between miR-19b and TGF-βl signaling of hepatic stellate cell proliferaiton[D]. Urumqi: Xinjiang University, 2014: 82. (in Chinese) |
| [12] | ( 王丽敏. miR-19b与TGF-β1交互作用对肝星状细胞增殖影响机制研究[D]. 乌鲁木齐: 新疆大学, 2014: 82.) |
| [13] | Boon MR,, van der Horst G,, van der Pluijm G, et al. Bone morphogenetic protein 7: a broad-spectrum growth factor with multiple target therapeutic potency[J]. Cytokine Growth Factor Rev, 2011, 22(4): 221-229. |
| [14] | Hellerbrand C,, Stefanovic B,, Giordano F, et al. The role of TGFβ1 in initiating hepatic stellate cell activation in vivo[J]. J Hepatol, 1999, 30(1): 77-87. |
| [15] | Drabsch Y,, Dijke PT. TGF-β signalling and its role in cancer progression and metastasis[J]. Cancer Metastasis Rev, 2012, 31(3): 553-568. |
| [16] | Dudás J,, Kovalszky I,, Gallai M, et al. Expression of decorin, transforming growth factor-beta1, tissue inhibitor metalloproteinase 1 and 2, and type IV collagenases in chronic hepatitis[J]. Am J Clin Pathol, 2001, 115(5): 725-735. |
| [17] | Liu YM,, Abudounnasier G,, Zhang TC, et al. Increased expression of TGF-β1 in correlation with liver fibrosis during Echinococcus granulosus infection in mice[J]. Korean J Parasitol, 2016, 54(4): 519-525. |
| [18] | Wu XW,, Chen XL,, Peng XY, et al. The special expressions of TGF-β1 and TNF-α in the pericystic layer of hepatic hydatid cyst[J]. Chin J Endem, 2004, 23(4): 311-313. (in Chinese) |
| [18] | ( 吴向未,, 陈雪玲,, 彭心宇, 等. TGF-β1、TNF-α mRNA在肝包虫囊肿周围人体纤维囊壁中的特异性分层表达[J]. 中国地方病学杂志, 2004, 23(4): 311-313.) |
| [19] | Hedger MP,, de Kretser DM. The activins and their binding protein, follistatin: diagnostic and therapeutic targets in inflammatory disease and fibrosis[J]. Cytokine Growth Factor Rev, 2013, 24(3): 285-295. |
| [20] | Masszi A,, Kapus A. Smaddening complexity: the role of Smad3 in epithelial-myofibroblast transition[J]. Cells Tissues Organs, 2011, 193(1/2): 41-52. |
| [21] | Wang JH,, Zhang CS,, Wei XF, et al. TGF-β and TGF-β/Smad signaling in the interactions between Echinococcus multilocularis and its hosts[J]. PLoS One, 2013, 8(2): e55379. |
| [22] | Wei XF,, Shao YM,, Wang JH, et al. The expression and significance of TGF-β1, TβRⅠ, and p-Smad2/3 during the middle stages of infection in BALB/c mice infected with Echinococcus multilocularis[J]. J Pathog Biol, 2010, 5(12): 895-897, 900, 876. (in Chinese) |
| [22] | ( 魏绪法,, 邵英梅,, 王俊华, 等. 泡球蚴感染中期小鼠肝脏病灶周围肉芽肿TGF-β1及其受体TβRⅠ和p-Smad2/3的表达及意义[J]. 中国病原生物学杂志, 2010, 5(12): 895-897, 900, 876.) |
| [23] | Shen DF,, Yang YW,, Zhu HH. Effects of Smad2, Smad5 and Smad7 proteins on fibrosis progression of vesicular hepatic echinococcosis[J]. Chin J Exp Surg, 2022(2): 269-272. (in Chinese) |
| [23] | ( 申东方,, 杨育文,, 朱海宏. Smad2、Smad5、Smad7蛋白对泡型肝包虫病纤维化进程的影响[J]. 中华实验外科杂志, 2022(2): 269-272.) |
| [24] | Hanafusa H,, Ninomiya-Tsuji J,, Masuyama N, et al. Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-β-induced gene expression[J]. J Biol Chem, 1999, 274(38): 27161-27167. |
| [25] | Engel ME,, McDonnell MA,, Law BK, et al. Interdependent SMAD and JNK signaling in transforming growth factor-β-mediated transcription[J]. J Biol Chem, 1999, 274(52): 37413-37420. |
| [26] | Ren B. Effect of Echinococcus multilocularis vesicle fluid (EmF) on mitogen activated protein kinase (MAPK) in the hepatic stellate cell of rats[D]. Xining: Qinghai University, 2014: 35. (in Chinese) |
| [26] | ( 任宾. 泡球蚴囊液对大鼠肝星状细胞MAPK信号通路影响的初步研究[D]. 西宁: 青海大学, 2014: 35.) |
| [27] | Cao T. Expression and significance of p38MAPK, BMP7 and TGF-β1 protein in hepatic alveolar echinococcosis[D]. Xining: Qinghai University, 2021: 44. (in Chinese) |
| [27] | ( 曹涛. p38MAPK、BMP7、TGF-β1蛋白在肝多房棘球蚴病组织中的表达及意义[D]. 西宁: 青海大学, 2021: 44.) |
| [28] | Li ZW,, Dong JH,, Wang HJ, et al. Expression and significance of Smad2 and P38MAPK in hepatic tissues next to Echinococcus multilocularis[J]. Chin J Zoonoses, 2016, 32(3): 246-250, 255. (in Chinese) |
| [28] | ( 李振伟,, 董家鸿,, 王海久, 等. Smad2及P38MAPK在泡球蚴病灶旁肝脏组织中的表达及意义[J]. 中国人兽共患病学报, 2016, 32(3): 246-250, 255.) |
| [29] | Zhang PQ,, Liu N,, Wang LY. BMP-/Smads/TGF-β1 signaling pathway and renal interstitial fibrosis[J]. Med Recapitul, 2008, 14(1): 13-15. (in Chinese) |
| [29] | ( 张佩青,, 刘娜,, 王丽彦. BMP-7/Smads/TGF-β1信号转导通路与肾间质纤维化[J]. 医学综述, 2008, 14(1): 13-15.) |
| [30] | Yuan B,, Wu ZM. MMP-2 silencing reduces the osteogenic transformation of fibroblasts by inhibiting the activation of the BMP/Smad pathway in ankylosing spondylitis[J]. Oncol Lett, 2018, 15(3): 3281-3286. |
| [31] | Li D. Expression and significance P38, TGF-β1 and BMP-7 in liver fibrosis caused by hepatic alveolar echinococcosis[D]. Xining: Qinghai University, 2020: 43. (in Chinese) |
| [31] | ( 李栋. P38、TGF-β1、BMP-7在泡型肝包虫病纤维化中的基因表达及意义[D]. 西宁: 青海大学, 2020: 43.) |
| [32] | Yoshiji H,, Kuriyama S,, Yoshii J, et al. Vascular endothelial growth factor and receptor interaction is a prerequisite for murine hepatic fibrogenesis[J]. Gut, 2003, 52(9): 1347-1354. |
| [33] | Yang L,, Kwon J,, Popov Y, et al. Vascular endothelial growth factor promotes fibrosis resolution and repair in mice[J]. Gastroenterology, 2014, 146(5): 1339-1350. |
| [34] | Kantari-Mimoun C,, Castells M,, Klose R, et al. Resolution of liver fibrosis requires myeloid cell-driven sinusoidal angiogenesis[J]. Hepatology, 2015, 61(6): 2042-2055. |
| [35] | Li Q. Expressions of vascular endothelial growth factor, microvessel density-CD34 in hepatic alveolar hydatid tissue in gerbil model[D]. Shihezi: Shihezi University, 2016: 51. (in Chinese) |
| [35] | ( 李琪. 接种泡状棘球蚴沙鼠体内血清及组织中VEGF、CD34的表达[D]. 石河子: 石河子大学, 2016: 51.) |
| [36] | Borkham-Kamphorst E,, Ostendorf T, et al. Pro-fibrogenic potential of PDGF-D in liver fibrosis[J]. J Hepatol, 2007, 46(6): 1064-1074. |
| [37] | Chen XL,, Wu XW,, Peng XY, et al. Delaminated expressions of PDGF and TNF-α in the pericystic tissues of hepatic hydatid cysts[J]. Curr Immunol, 2004, 24(3): 207-209. (in Chinese) |
| [37] | ( 陈雪玲,, 吴向未,, 彭心宇,, 等. PDGF、 TNF-α在人肝细粒棘球蚴囊壁周围组织的分层表达[J]. 现代免疫学, 2004, 24(3): 207-209.) |
| [38] | Huang GC,, Brigstock DR. Regulation of hepatic stellate cells by connective tissue growth factor[J]. Front Biosci (Landmark Ed), 2012, 17(7): 2495-2507. |
| [39] | Liu Y,, Liu H,, Meyer C, et al. Transforming growth factor-β (TGF-β)-mediated connective tissue growth factor (CTGF) expression in hepatic stellate cells requires Stat3 signaling activation[J]. J Biol Chem, 2013, 288(42): 30708-30719. |
| [40] | Jiang T. Expression and significance of CTGF in the pericystic layers of hepatic hydatid cyst[D]. Shihezi: Shihezi University, 2007: 47. (in Chinese) |
| [40] | ( 姜涛. CTGF在肝包虫囊壁及周围肝组织中的表达与意义[D]. 石河子: 石河子大学, 2007: 47.) |
| [41] | Luedde T,, Schwabe RF. NF-κB in the liver: linking injury, fibrosis and hepatocellular carcinoma[J]. Nat Rev Gastroenterol Hepatol, 2011, 8(2): 108-118. |
| [42] | Seki E,, de Minicis S,, Österreicher CH, et al. TLR4 enhances TGF-β signaling and hepatic fibrosis[J]. Nat Med, 2007, 13(11): 1324-1332. |
| [43] | Ma WM,, Sang W,, AIMAITI YS, et al. Roles of nuclear factor-κB/myeloid differentiation factor 88 in the liver fibrosis of cystic echinococcosis patients[J]. Chin J Parasitol Parasit Dis, 2021, 39(6): 779-784. (in Chinese) |
| [43] | ( 马文梅,, 桑伟,, 艾麦提·牙森, 等. 核因子-κB/髓样分化分子88在细粒棘球蚴病患者肝纤维化中的作用[J]. 中国寄生虫学与寄生虫病杂志, 2021, 39(6): 779-784.) |
| [44] | Bi XJ. miR-133a effect study on Echinococcus multilocularis induced hepatic stellate cell activation in vitro and liver fibrosis in infected mice in vivo[D]. Urumqi: Xinjiang Medical University, 2016: 59. (in Chinese) |
| [44] | ( 毕晓娟. miRNA-133a在泡球蚴感染所致肝星状细胞活化中作用及与肝纤维化的关系[D]. 乌鲁木齐: 新疆医科大学, 2016: 59.) |
| [45] | Ye JW,, Liu H,, Lv GD, et al. The expression of miR-106b-25 microRNA cluster in the liver of mice with Echinococcus multilocularis infected[J]. J Clin Exp Med, 2016, 15(23): 2296-2300. (in Chinese) |
| [45] | ( 叶建蔚,, 刘辉,, 吕国栋, 等. miR-106b-25基因簇在小鼠肝泡型包虫病中的表达[J]. 临床和实验医学杂志, 2016, 15(23): 2296-2300.) |
| [46] | Qin BD. Screening of microRNA expression profile in the primary biliary cirrhosis and study on its function[D]. Shanghai: Second Military Medical University, 2013: 66. (in Chinese) |
| [46] | ( 秦保东. 原发性胆汁性肝硬化microRNA表达谱的检测及其功能研究[D]. 上海: 第二军医大学, 2013: 66.) |
| [47] | Zhang C,, Wang L,, Ali T, et al. Hydatid cyst fluid promotes peri-cystic fibrosis in cystic echinococcosis by suppressing miR-19 expression[J]. Parasit Vectors, 2016, 9(1): 278. |
| [48] | Zhang X,, Gong W,, Cao S, et al. Comprehensive analysis of non-coding RNA profiles of exosome-like vesicles from the protoscoleces and hydatid cyst fluid of Echinococcus granulosus[J]. Front Cell Infect Microbiol, 2020, 10: 316. |
| [49] | Shen ZF,, Xu XS,, Sun JL. Regulation mechanism of miR-125b to cardiac fibroblasts after myocardial infarction[J]. Chin J Evid Based Cardiovasc Med, 2018, 10(7): 853-856, 860. (in Chinese) |
| [49] | ( 沈志方,, 许学升,, 孙继兰. miR-125b对心肌梗死后成纤维细胞的调控机制研究[J]. 中国循证心血管医学杂志, 2018, 10(7): 853-856, 860.) |
| [50] | Bakhti K. Identification of expression profile of circular RNA in the outer capsule of hepatic hydatid and its preliminary mechanism[D]. Urumqi: Xinjiang Medical University, 2021: 120.(in Chinese) |
| [50] | 巴合提·卡力甫. 环状RNA在肝包虫外囊组织中表达谱鉴定及初步机制研究[D]. 乌鲁木齐: 新疆医科大学, 2021: 120.) |
/
| 〈 |
|
〉 |