收稿日期: 2021-12-27
修回日期: 2022-01-20
网络出版日期: 2022-09-07
基金资助
云南省教育厅科学研究基金项目(2021J0711);国家自然科学基金面上项目(81860486)
Research progress on clinical trials of schistosomiasis vaccine candidates
Received date: 2021-12-27
Revised date: 2022-01-20
Online published: 2022-09-07
Supported by
Scientific Research Fund Project of Yunnan Education Department(2021J0711);National Natural Science Foundation of China(81860486)
陈兵 , 张国莉 , 张高红 . 血吸虫病候选疫苗临床研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2022 , 40(4) : 511 -515 . DOI: 10.12140/j.issn.1000-7423.2022.04.015
Schistosomiasis is a wide-spread parasitic zoonosis caused by Schistosoma, which seriously harms human health and affects socioeconomic development worldwide. Schistosomiasis vaccines have attracted much attention as they will contribute not only to reducing the over-reliance on praziquantel for the treatment of this disease but also to achieving the goal of disease control and elimination. There have been no schistosomiasis vaccines available until now; however, four schistosomiasis vaccine candidates, glutathione S-transferase, fatty acid binding protein, tetraspanin-2 and calpain, have entered human clinical trials. This paper reviewed the clinical research progress and challenges of the four schistosomiasis vaccine candidates to provide insights into developing vaccines for schistosomiasis and other helminthiases in China.
Key words： Schistosomiasis; Vaccine; Antigen; Human clinical trial
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