收稿日期: 2020-10-05
修回日期: 2020-11-06
网络出版日期: 2021-05-28
基金资助
教育部春晖计划合作科研项目(Z2017018);河北师范大学重点基金项目(L2020Z06)
Research progress on tick protective antigens
Received date: 2020-10-05
Revised date: 2020-11-06
Online published: 2021-05-28
Supported by
Chunhui Program from the Ministry of Education of China(Z2017018);Foundation of Hebei Normal University(L2020Z06)
吕立红 , 张金成 , 胡永红 . 蜱类保护性抗原研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2021 , 39(4) : 542 -547 . DOI: 10.12140/j.issn.1000-7423.2021.04.020
Ticks are obligate hematophagous ectoparasites that can transmit a variety of pathogens, having harmful impacts on human health and the husbandry industry. Screening for efficient protective antigens to develop anti-tick vaccines has become a safe and effective strategy for tick control. This paper briefly introduces the commercial Bm86 protective antigen, and summarizes current status of protective antigens with different characteristics derived from tick salivary glands, midgut, gonads and eggs, as well as protective antigens of enzymes, protease inhibitors and conservative proteins. The review will provide a scientific basis for the development of anti-tick vaccines.
Key words： Tick; Protective antigen; Anti-tick vaccine
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