收稿日期: 2020-11-19
修回日期: 2021-02-17
网络出版日期: 2021-08-05
基金资助
国家自然科学基金面上项目(81971955);广东省自然科学基金面上项目(2019A1515011667);广东省自然科学基金面上项目(2021A1515012115);2021年广东省研究生教育创新计划项目(2021SFKC003);2021年中山大学校级本科教学质量工程项目（中大教务［2021］93号）;2020年中山大学校级本科教学质量工程项目(中大教务[2020]72 号]);中山大学热带病防治研究教育部重点实验室开放基金(2020ZX02)
The interplay between Toxoplasma gondii infection and autophagy in host cells
Received date: 2020-11-19
Revised date: 2021-02-17
Online published: 2021-08-05
Supported by
National Natural Science Foundation of China(81971955);Natural Science Foundation of Guangdong Province(2019A1515011667);Natural Science Foundation of Guangdong Province(2021A1515012115);2021 Graduate Education Innovation Plan Project of Guangdong Province(2021SFKC003);Undergraduate Teaching Quality Engineering Project of Sun Yat-sen University (SYSU Undergraduate Education [2021]93);Undergraduate Teaching Quality Engineering Project of Sun Yat-sen University (SYSU Undergraduate Education [2020]72);Open Project of Key Laboratory of Tropical Disease Control of Ministry of Education, Sun Yat-sen University(2020ZX02)
侯永恒 , 吕芳丽 . 弓形虫感染与宿主细胞自噬的相互作用[J]. 中国寄生虫学与寄生虫病杂志, 2021 , 39(4) : 537 -542 . DOI: 10.12140/j.issn.1000-7423.2021.04.019
Toxoplasma gondii is an important obligate intracellular pathogenic protozoan with worldwide distribution that may cause zoonotic toxoplasmosis, severely impacting the human health and the economy of animal husbandry. Studies have shown that the type I strain of T. gondii can escape from the killing effect of autophagy in host cells by changing the expression of autophagy-related proteins in the host, while the type Ⅱ and Ⅲ strains of T. gondii can be effectively cleared up or suppressed by the autophagy system of host cells. This review provides an update on the interplay between T. gondii infection and host cell autophagy system and the related molecular mechanisms.
Key words： Toxoplasma gondii; Infection; Host cell; Autophagy; Interplay
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