收稿日期: 2020-08-20
修回日期: 2020-09-25
网络出版日期: 2021-07-05
基金资助
国家自然科学基金(81871681);江南大学研究生科研与实践创新计划项目(1282050205198168)
Research progress on the treatment of malaria with artemisinin and its derivatives
Received date: 2020-08-20
Revised date: 2020-09-25
Online published: 2021-07-05
Supported by
National Natural Science Foundation of China(81871681);Research and Practice Innovation Program for University-level postgraduates of Jiangnan University(1282050205198168)
杨博 , 孙毅凡 , 雷瑶 , 程洋 . 青蒿素及其衍生物治疗疟疾的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2021 , 39(3) : 393 -402 . DOI: 10.12140/j.issn.1000-7423.2021.03.016
Artemisinin is a safe antimalarial drug. Artemisinin-based drug combinations have been recommended by the World Health Organization as the first-line treatment for falciparum malaria. However, artemisinin resistance is emerging in the treatment of malaria, and has gradually become a major threat to malaria control. Artemisinin drugs have attracted much attention due to the quick effect and low toxicity. In recent years, research and clinical application of artemisinin and its derivatives have been continuously carried out in depth. This paper reviews the antimalarial mechanism, drug resistance phenomenon and mechanism and clinical application of artemisinin drugs, in order to provide valuable reference of further research and application of artemisinin and its derivatives.
Key words： Artemisinin; Artemisinin derivatives; Artemisinin resistance; Malaria
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