收稿日期: 2020-12-31
修回日期: 2021-02-02
网络出版日期: 2021-07-05
基金资助
四川省科技计划(2018SZ0116)
Analysis of characteristics of echinococcosis patients in Shiqu County at different time periods
Received date: 2020-12-31
Revised date: 2021-02-02
Online published: 2021-07-05
Supported by
Science and Technology Projects of Sichuan Province(2018SZ0116)
2000—2002年和2014—2017年分别采用整群抽样的方式对石渠县7、8个乡镇中的行政村进行调查,采用超声影像学检查辅以血清学检测的方法对棘球蚴病患者进行诊断,比较两时间段内棘球蚴病患者性别、年龄、病灶大小、分型等的构成特点。2000—2002和2014—2017年分别调查416例和2 090例棘球蚴病患者。石渠县细粒棘球蚴病（CE）患者比例由2000—2002年的51.9%（216/416）下降至2014—2017年的39.8%（832/2 090）,多房棘球蚴病（AE）患者比例由2000—2002年的48.1%（200/416）上升至2014—2017年的57.4%（1 200/2 090）（P < 0.05）;CL、CE1、CE2患者比例由2000—2002年的2.4%（10/416）、18.0%（75/416）、13.0%（54/416）分别下降至2014—2017年的0.7%（14/2 090）、4.6%（96/2 090）、6.0%（125/2 090）（ P < 0.05）,CE3、CE4、CE5患者比例由2000—2002年的5.5%（23/416）、11.5%（48/416）、1.4%（6/416）分别上升至2014—2017年11.1%（232/2 090）、14.1%（294/2 090）、3.4%（71/2 090）（ P < 0.05）;AE钙化结节型患者比例由2000—2002年的10.3%（43/416）上升至2014—2017年的21.2%（444/2 090）（ P < 0.05）,AE液化空洞型患者比例由2000—2002年的18.3%（76/416）下降至2014—2017年的13.6%（284/2 090）（ P < 0.05）,且病灶直径< 5 cm的AE患者比例由2000—2002年的15.1%（63/416）上升至2014—2017年的25.7%（523/2 032）（ P < 0.05）;CE患者比例,21~30岁年龄组2000—2002年（10.6%,44/416）高于2014—2017年（4.5%,92/2 032）（ P < 0.05）,41~50岁及≥ 61岁年龄组2000—2002年（8.7%,36/416;5.3%,22/416）低于2014—2017年（9.8%,199/2 032;6.9%,141/2 032）（ P < 0.05）。石渠县经过十余年的综合防治,棘球蚴病患者的构成情况呈现CE患者比例降低,AE患者比例增高,病灶分型、大小、年龄构成也有相应变化。
廖沙 , 喻文杰 , 张光葭 , 何伟 , 王奇 , 李调英 , 陈兴旺 , 王谦 . 不同时间段石渠县棘球蚴病患者特征分析[J]. 中国寄生虫学与寄生虫病杂志, 2021 , 39(3) : 332 -336 . DOI: 10.12140/j.issn.1000-7423.2021.03.018
Mass screening for echinococcosis was conducted in the administrative villages in 7 and 8 towns in Shiqu county using the random cluster sampling method from 2000 to 2002 and from 2014 to 2017. Ultrasonographic imaging and serological tests were applied to diagnose echinococcosis. The sex, age, lesion size and classification of patients were compared between the two time periods. A total of 416 and 2 090 echinococcosis patients were investigated during 2000—2002 and 2014—2017, respectively. The proportion of cystic echinococcosis (CE) patients in Shiqu county decreased from 51.9% (216/416) in 2000—2002 to 39.8% (832/2 090) in 2014—2017, while the proportion of alveolar echinococcosis (AE) patients increased from 48.1% (200/416) in 2000—2002 to 57.4% (1 200/2 090) in 2014—2017 (P < 0.05). The proportions of CL, CE1 and CE2 type patients decreased from 2.4% (10/416), 18.0% (75/416) and 13.0% (54/416) in 2000—2002 to 0.7% (14/2 090), 4.6% (96/2 090) and 6.0% (125/2 090) in 2014—2017 ( P < 0.05). The proportions of CE3, CE4 and CE5 patients increased from 5.5% (23/416), 11.5% (48/416) and 1.4% (6/416) in 2000—2002 to 11.1% (232/2 090), 14.1% (294/2 090) and 3.4% (71/2 090) in 2014—2017, respectively ( P < 0.05). The proportion of AE patients with calcification and nodular increased from 10.3% (43/416) in 2000—2002 to 21.2% (444/2 090) in 2014—2017, while the proportion of AE patients with central necrosis lesion decreased from 18.3% (76/416) in 2000—2002 to 13.6% (284/2 090) in 2014—2017 ( P < 0.05); meanwhile, the proportion of AE patients with lesion diameter < 5 cm increased from 15.1% (63/416) in 2000—2002 to 25.7% (523/2 032) in 2014—2017 ( P < 0.05). The proportion of CE patients aged 21 to 30 years decreased from 2000—2002 (10.6%, 44/416) to 2014—2017 (4.5%, 92/2 032)( P < 0.05), and the proportion of CE patients aged 41-50 years and over 60 years increased from 2000—2002(8.7%, 36/416; 5.3%, 22/416) to 2014—2017(9.8%, 199/2 032; 6.9%, 141/2 032), respectively ( P < 0.05). After more than 10 years’ comprehensive prevention and control for echinococcosis in Shiqu county, the proportion of the patients showed changes with the CE type decreased and AE type increased, and correspondently, changes were seen in the composition of patients with different lesion classifications and sizes, and ages.
Key words： Shiqu County; Echinococcosis; Patients; Characteristics
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