收稿日期: 2020-02-22
网络出版日期: 2020-11-12
基金资助
国家自然科学基金项目(81702025);河南省科技攻关计划项目(182102310220);新乡医学院博士科研启动基金(XYBSKYZZ201504)
Advances in research on exosomes of Toxoplasma spp.
Received date: 2020-02-22
Online published: 2020-11-12
Supported by
National Natural Science Foundation of China(81702025);Science and Technology Project of Henan Province(182102310220);Doctoral Research Fund of Xinxiang Medical University(XYBSKYZZ201504)
李朋举 , 左素琼 , 段玉娟 , 李浩然 , 张振超 , 李祥瑞 , 王帅 . 弓形虫外泌体研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2020 , 38(5) : 653 -657 . DOI: 10.12140/j.issn.1000-7423.2020.05.020
Exosomes are a type of extracellular vesicles secreted by a variety of cells, and contain many active components such as proteins, lipids, and nucleic acids. Studies have shown that a majority of parasites can secrete exosomes, which play important roles in mediating communications between parasites and host cells, regulating host immune responses, as well as transmitting pathogenic factors, drug resistance-associated genes and differentiation factors. In addition, exosome-based therapies and vaccine development are still under the way. In this paper, we summarize the biological characteristics and functions of exosomes secreted by Toxoplasma spp., and discuss their application potentials.
Key words： Toxoplasma; Exosome; Immunomodulation; Application
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