收稿日期: 2019-12-09
网络出版日期: 2020-09-09
基金资助
云南省高层次卫生健康技术人才培养专项经费(媒介生物控制学H-2018072);卫生部寄生虫病原与媒介生物学重点实验室开放课题(WSBKTKT-201602)
Clinical features of 65 cases of fascioliasis in Yunnan Province
Received date: 2019-12-09
Online published: 2020-09-09
Supported by
High-level Health and Technical Talents Cultivating Special Fund in Yunnan Province(媒介生物控制学H-2018072);Key Laboratory of Parasite Vector Biology, Ministry of Health(WSBKTKT-201602)
收集2011年11月-2018年11月云南省6地(市)片形吸虫病病例的临床资料。65例病例中,男28例,女37例。职业以农民为主,占64.6%(42/65),民族以汉族为主,占89.2%(58/65),病例主要来自大理地区,占72.3%(47/65)。65例病例均食过凉拌生菜,6例喝过生的山沟箐水。18例涉及5户家庭,有家庭聚集现象。全部病例均因不同程度发热、腹痛等就诊,血常规均提示嗜酸粒细胞增高,腹部彩超或CT(和/或)MRI检查结果示,以肝脏为主不同程度的脏器损害;粪检片形吸虫卵阳性率23.1%(15/65),血清片形吸虫抗体检测强阳性58例,阳性7例,阳性率100%(65/65)。全部病例经三氯苯达唑治疗后发热、腹痛明显好转,血常规嗜酸粒细胞、肝脏等病变也恢复正常。
李芹翠 , 陈凤 , 顾伟 , 杨磊 . 云南省65例片形吸虫病临床特点[J]. 中国寄生虫学与寄生虫病杂志, 2020 , 38(4) : 521 -523 . DOI: 10.12140/j.issn.1000-7423.2020.04.022
Clinical data of fascioliasis patients recorded in 6 prefectures(cities) in Yunnan Province were collected from November 2011 to November 2018. A total of 65 cases were enrolled, including 28 males and 37 females. The majority of them were farmers (64.6%, 42/65), being Han ethnicity (89.2%, 58/65), and coming from Dali District(72.3%, 47/65). All of the 65 cases had eaten raw vegetables, and 6 of them had drunk unboiled gully water. Eighteen cases involving 5 families had family aggregative phenomenon. All the cases visited hospital for suffering fever and abdominal pain. Blood routine tests showed increased eosinophilia; abdominal color ultrasound scanning or CT (and/or) MRI examination suggested varying degrees of organ lesion particularly in the liver; and fecal sample examination revealed a positive rate of Fasciola eggs of 23.1% (15/65). The test for serum antibody against Fasciola found 58 strongly positive and 7 positive, resulting in a positive rate of 100% (65/65). All of the cases showed obvious improvement in symptoms of fever and abdominal pain after treatment with trichlorobendazole, and blood routine tests showed that eosinophils and liver lesions gradually returned to normal.
Key words: Fasioliasis; Organ injury; Trichlorobendazole; Serum antibody
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