蠕形螨寄生对人面部皮肤生理功能的影响

doi:10.12140/j.issn.1000-7423.2026.01.020

中国寄生虫学与寄生虫病杂志 ›› 2026, Vol. 44 ›› Issue (1): 137-140.doi: 10.12140/j.issn.1000-7423.2026.01.020

蠕形螨寄生对人面部皮肤生理功能的影响

刘思文¹()(), 张大存², 李志强¹, 刘春生¹, 陈思³, 田如玉³, 黄泽宇³, 宋子月³, 秦蕾³, 张汝芝³, 刘小绿⁵, 谷生丽¹^,⁴, 湛孝东¹^,³^,⁴^,^*()()

¹ 皖南医科大学医学寄生虫学教研室，安徽芜湖 241000
² 山东省九鑫生物工程有限公司，山东泰安 271000
³ 皖南医科大学第二附属医院皮肤科，安徽芜湖 241000
⁴ 芜湖市螨类检验与防控工程技术研究中心，安徽芜湖 241000
⁵ 安徽国际旅行卫生保健中心（合肥海关口岸门诊部）

收稿日期:2025-07-08 修回日期:2025-10-21 出版日期:2026-02-28 发布日期:2026-02-14
通讯作者: * 湛孝东（ORCID:0000-0002-7224-5248），男，博士，教授，从事螨类疾病防控与预防研究。E-mail: xdzhan@126.com
作者简介:刘思文（ORCID:0009-0003-8813-4061），女，硕士研究生，从事螨类防控与预防研究。E-mail：2310543412@qq.com
基金资助:
企业委托研发项目(H202313)

Impact of Demodex infestation on the physiological functions of human facial skin

LIU Siwen¹()(), ZHANG Dacun², LI Zhiqiang¹, LIU Chunsheng¹, CHEN Si³, TIAN Ruyu³, HUANG Zeyu³, SONG Ziyue³, QIN Lei³, ZHANG Ruzhi³, LIU Xiaolv⁵, GU Shengli¹^,⁴, ZHAN Xiaodong¹^,³^,⁴^,^*()()

¹ Department of Medical Parasitology, Wannan Medical University, Wuhu 241000, Anhui, China
² Shandong Jiuxin Bioengineering Co., Ltd, Tai’an 271000, Shandong, China
³ Department of Dermatology, the Second Affiliated Hospital of Wannan Medical University, Wuhu 241000, Anhui, China
⁴ Wuhu Mite Inspection and Control Engineering Technology Research Center, Wuhu 241000, Anhui, China
⁵ Anhui International Travel Health Care Center (Hefei Customs Port Outpatient Department), Hefei 230000, Anhui, China

Received:2025-07-08 Revised:2025-10-21 Online:2026-02-28 Published:2026-02-14
Contact: *E-mail: xdzhan@126.com
Supported by:
Enterprise-commissioned Research and Development Project(H202313)

摘要/Abstract

摘要：

为探讨蠕形螨寄生对人面部皮肤生理功能的影响，采用透明胶带法对某高校大学生（240人）进行蠕形螨阳性患者筛选，根据纳入标准筛选到32例蠕形螨阳性患者。治疗前对蠕形螨阳性患者进行皮肤生理功能测试（皮肤红斑、皮肤黑色素、皮肤水分、皮肤油脂、毛孔、皮肤弹性、皮肤光泽）和肌肤影像分析。测试后患者服用甲硝唑片进行治疗，剂量为每次0.4 g，每日3次，连续治疗7 d。治疗结束后2周，采用透明胶带法检测患者面部皮肤，确认面部无螨后，随机选取左侧面部无皮损区域进行皮肤生理功能测试和肌肤影像分析，比较治疗前后面部皮肤各项生理指标和皮肤成像的差异。结果显示，治疗后蠕形螨阳性患者面部皮肤红斑指数为16.42 ± 16.48、油脂分泌量为（18.59 ± 3.58）µg/cm²、毛孔占比为（4.13 ± 0.31）%、光泽度为（3.59 ± 0.22）GU，均较治疗前的20.99 ± 17.79、（22.95 ± 4.42）µg/cm²、（4.61 ± 0.33）%、（4.07 ± 0.23）GU均降低（t = 2.26、3.86、3.24、2.29，均P < 0.05）；治疗后的皮肤水分分泌量为（51.06 ± 11.41）a.u.，较治疗前的（39.18 ± 9.30）a.u.升高（t = -5.31，P < 0.01）；治疗后的皮肤黑色素值为151.74 ± 6.80、皮肤弹性R₂为63.04 ± 0.98，均较治疗前的155.56 ± 6.50、64.77 ± 1.51降低，但差异无统计学意义（t = 1.14、1.09，均P > 0.05）。肌肤影像分析结果显示，近红外影像下，蠕形螨阳性患者治疗前的面部皮肤泛红、大面积毛细血管扩张；治疗后泛红区域减少、毛细血管扩张和炎症性痤疮明显减轻。红区影像下，蠕形螨阳性患者治疗前面部皮肤有大面积深红色，治疗后深红区域变小且部分呈粉红色，深层炎症区域明显减小。结果提示蠕形螨寄生可影响皮肤生理功能，导致皮肤水油分泌平衡失调，进而破坏皮肤屏障功能，促进毛细血管扩张和血红蛋白含量增加。

关键词: 蠕形螨, 面部皮肤, 皮肤生理指标, 肌肤影像分析

Abstract:

To investigate the impact of Demodex mite infestation on the physiological functions of human facial skin, 240 university students were screened for Demodex infections using the transparent adhesive tape method. Base on the inclusion criteria, 32 students were tested positive for Demodex. Skin physiological function tests (skin erythema, melanin content, moisture, sebum, pore size, elasticity, and gloss) and skin image analysis were conducted among subjects positive for Demodex prior to treatment. Following testing, patients were given oral metronidazole tablets at a single dose of 0.4 g, three times daily, for successive 7 days. Facial skin was tested for presence of mites with transparent adhesive tapes 2 weeks post-treatment. Then, non-affected areas in the left-side mite-free face were randomly sampled for skin physiological function tests and skin image analysis, and the skin physiological and imaging parameters on face were compared between pre- and post-treatment. The facial skin erythema value, sebum secretion, proportion of skin pores, and gloss were 16.42 ± 16.48, (18.59 ± 3.58) µg/cm², (4.13 ± 0.31)%, and (3.59 ± 0.22) GU, respectively among patients tested positive for Demodex post-treatment, which were significantly lower than those [20.99 ± 17.79, (22.95 ± 4.42) µg/cm², (4.61 ± 0.33)%, (4.07 ± 0.23) GU] pre-treatment (t = 2.26, 3.86, 3.24, 2.29; all P < 0.05). The skin water content higher post-treatment than pre-treatment [(51.06 ± 11.41) a.u. vs. (39.18 ± 9.30) a.u.; t = -5.31, P < 0.01], and the melanin content (151.74 ± 6.80 vs. 155.56 ± 6.50; t = 1.14, P > 0.05) and gross elasticity (R₂) (63.04 ± 0.98 vs. 64.77 ± 1.51; t = 1.09, P > 0.05) were numerically lower post-treatment than pre-treatment. Skin image analysis revealed that, on near-infrared images, patients positive for Demodex exhibited facial erythema and extensive capillary dilation prior to treatment, and reduced erythematous areas and remarkable alleviation of capillary dilation and inflammatory acne post-treatment. On red channel images, extensive deep red areas were found on facial skin among patients positive for Demodex prior to treatment, and diminished deep red zones and partially turned pink were observed post-treatment, with markedly reduced deep inflammatory areas. These findings suggest that Demodex infestation may affect skin physiological functions, and lead to imbalance of water and sebum secretion in skin, thereby impairing the skin barrier function, and promoting capillary dilation, and increasing hemoglobin levels.

Key words: Demodex, Facial skin, Skin physiological parameter, Skin image analysis

中图分类号:

757.3

刘思文, 张大存, 李志强, 刘春生, 陈思, 田如玉, 黄泽宇, 宋子月, 秦蕾, 张汝芝, 刘小绿, 谷生丽, 湛孝东. 蠕形螨寄生对人面部皮肤生理功能的影响[J]. 中国寄生虫学与寄生虫病杂志, 2026, 44(1): 137-140.

LIU Siwen, ZHANG Dacun, LI Zhiqiang, LIU Chunsheng, CHEN Si, TIAN Ruyu, HUANG Zeyu, SONG Ziyue, QIN Lei, ZHANG Ruzhi, LIU Xiaolv, GU Shengli, ZHAN Xiaodong. Impact of Demodex infestation on the physiological functions of human facial skin[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2026, 44(1): 137-140.

图/表 2

参考文献 32

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蠕形螨寄生对人面部皮肤生理功能的影响

Impact of Demodex infestation on the physiological functions of human facial skin

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