中国寄生虫学与寄生虫病杂志 ›› 1997, Vol. 15 ›› Issue (3): 16-176.

• 实验报道 • 上一篇    下一篇

吡喹酮对体外猪囊尾蚴作用的观察

苏连杰1,张贵君1,傅起凤1,许桂兰2   

  1. 1 黑龙江中医药大学 哈尔滨 1500402 黑龙江省九三农管局中心医院 嫩江 161441
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1997-06-30 发布日期:1997-06-30

OBSERVATION ON THE IN VITRO EFFECT OF PRAZIQUANTEL ON CYSTICERCUS CELLULOSAE

Su Lianjie, Zhang Guijun, Fu Qifeng, Xu Guilan   

  1. Heilongjiang University of Traditional Chinese Medicine, Harbin 150040
  • Received:1900-01-01 Revised:1900-01-01 Online:1997-06-30 Published:1997-06-30

摘要:

目的: 观察吡喹酮对体外猪囊尾蚴的作用。方法: 应用扫描电镜和透射电镜方法, 分别对药物作用2 h、4 h、6 h后的猪囊尾蚴为实验样品, 对其扫描电镜特征及超微结构进行观察。结果: 猪囊尾蚴被药物作用后囊体挛缩变形、头节伸出, 体表溶蚀、皮层内质网和核糖体溶解、皮下层坏死。结论: 吡喹酮对猪囊尾蚴有强烈的杀伤作用。

关键词: 吡喹酮, 猪囊尾蚴, 扫描电镜, 透射电镜

Abstract:

AIM: To observe the effect of praziquantel on Cysticercus cellulosae in vitro. METHODS: After the Cysticercus cellulosae were incubated with praziquantel for 2, 4 and 6 h, the in vitro effects were observed by scanning and transmission electron microscopy. RESULTS: The structural and celullar changes of Cysticercus cellulosae under the action of praziquantel included the convulsion and deformity of the cyst body, corrosion of the body surface. Necrosis of the tegument and subtegument, and dissolution of the endoplasmic reticulum and ribosome. CONCLUSION: Praziquantel exerts strong action against Cysticercus cellulosae.

Key words: Praziquantel, Cysticercus cellulosae, SEM, TEM