中国寄生虫学与寄生虫病杂志 ›› 2000, Vol. 18 ›› Issue (2): 11-106.

• 论著 • 上一篇    下一篇

丝虫性乳糜尿患者外周血T淋巴细胞亚群的变化

顾祥田;高志刚;沈宝荣;胡桂芝;汤兴兰;马芹
  

  1. 山东省苍山县卫生防疫站!苍山277700
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2000-04-30 发布日期:2000-04-30

CHANGES IN T-LYMPHOCYTE SUBSETS OF PERIPHERAL BLOOD IN PATIENTS WITH FILARIAL CHYLURIA

GU Xiang-tian;GAO Zhi-gang;SHEN Bao-rong;HU Gui-zhi;TANG Xing-lan;MA Qin   

  1. Health and Anti-epidemic Station of Cangshan County;Shandong Province;Cangshan 277700
  • Received:1900-01-01 Revised:1900-01-01 Online:2000-04-30 Published:2000-04-30

摘要:   [目的 ]研究乳糜尿现症病人和非现症病人的外周血 T-淋巴细胞亚群 (CD3+ 、 CD4+ 和 CD8+ )的变化。[方法 ]采用 SAP法检测待检人群的外周血 T-淋巴细胞亚群。 [结果 ]现症病人的 CD3+、CD4+比非现症病人及健康人对照组显著减少 ,CD8+ 显著升高 ,CD4+ / CD8+ 明显降低 (P<0 .0 0 1) ,而且 CD4+ / CD8+ 的减低与乳糜蛋白尿的轻重程度呈正相关。非现症病人与健康人对照组 CD3+ 、 CD4+ 、 CD8+ 及 CD4+ / CD8+ 均在正常范围 ,无显著差异。 [结论 ]丝虫性乳糜尿患者机体免疫系统的比例失衡 ,免疫调节机能出现异常 ,且呈抑制趋势。

关键词: 丝虫病, 乳糜尿, T-淋巴细胞亚群

Abstract:  Objective] To study the changes in T-lymphocyte subsets CD4+:CD8+ of peripheral blood in 29 patients with present chyluria(PPC), 29 patients with chyluria history but without chyluria (PNPC) and 38 healthy controls. [Methods] The determination of CD3+, CD4+ and CD8+ was conducted using test reagents kits. [Results] The percentage of CD3+, CD4+ cell were signfcantly decreased in PPS group than in PNPC and healthy control group,the ratio of CD4+/CD8+ being under 1.0.The T-lymphocyte subsets (CD3+, CD4+, CD8+) and CD4+/CD8+ ratio of both PNPC and healthy control group were all within normal range. [Conclusion] The immune function of the patients with filarial chyluria was impaired in terms of the changes in T-lymphocyte subsets.

Key words: Filariasis, chyluria, T-lymphocyte subsets.