医学贝类及相关软体动物肽聚糖模式识别蛋白的研究进展

中国寄生虫学与寄生虫病杂志 ›› 2012, Vol. 30 ›› Issue (4): 13-312-316.

医学贝类及相关软体动物肽聚糖模式识别蛋白的研究进展

张宗禄1,2，郭云海2，罗泰昌1，张仪2 *

1 贵州师范大学生命科学学院，贵阳 550001； 2 中国疾病预防控制中心寄生虫病预防控制所，卫生部寄生虫病原与媒介生物学重点实验室，世界卫生组织疟疾、血吸虫病和丝虫病合作中心，上海 200025

出版日期:2012-08-30 发布日期:2012-10-26

Research Progress on Peptidoglycan Recognition Proteins of Medical Shells and Molluscs

ZHANG Zong-lu1,2，GUO Yun-hai2，LUO Tai-chang1，Zhang Yi2 *

1 School of Life Sciences, Guizhou Normal University, Guiyang 550001, China; 2 National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory of Parasite and Vector Biology, MOH; WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai 200025, China

Online:2012-08-30 Published:2012-10-26

摘要/Abstract

摘要： 肽聚糖模式识别蛋白（Peptidoglycan recognition proteins，PGRPs）是一类高度保守的模式识别受体，参与宿主早期对病原微生物的识别作用，可识别肽聚糖和含有肽聚糖的细菌，进而激发和调节下游系列宿主免疫反应。PGRPs广泛存在于昆虫、软体动物、棘皮动物和脊椎动物中。本文对医学贝类和相关软体动物PGRPs的基因、类型、结构、表达分布、功能和进化进行综述。

关键词: 医学贝类, 先天免疫, 肽聚糖模式识别蛋白

Abstract: Peptidoglycan recognition proteins （PGRPs） are highly conserved pattern recognition receptors in evolution, and they can recognize peptidoglycan（PGN） and bacteria that contain PGN in their cell wall component in early immune process of host, then provide signal transduction and activate a series of immune proteins. PGRPs are extensively present in insects, molluscs, echinoderms and vertebrates. Research progress and frontiers on PGRPs gene, type, structure, express localization, function, and evolution in medical molluscs and other snails were briefly reviewed in this article.

Key words: Medical molluscsa, Innate immunity, Peptidoglycan recognition proteins

张宗禄，郭云海，罗泰昌，张仪. 医学贝类及相关软体动物肽聚糖模式识别蛋白的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2012, 30(4): 13-312-316.

ZHANG Zong-lu，GUO Yun-hai，LUO Tai-chang，Zhang Yi. Research Progress on Peptidoglycan Recognition Proteins of Medical Shells and Molluscs[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2012, 30(4): 13-312-316.

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