中国寄生虫学与寄生虫病杂志 ›› 1991, Vol. 9 ›› Issue (2): 126-129.

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慢性血吸虫病患者IL-1和IL-2产生及反应状况的观察

张斌,沈伟侠   

  1. 南京市医学研究所免疫室
  • 收稿日期:2017-01-09 修回日期:2017-01-09 出版日期:1991-05-31 发布日期:2017-01-09

OBSERVATION ON THE PRODUCTION OF INTERLEUKIN-1 AND INTERLEUKIN-2 AND RESPONSE TO INTERLEUKIN-2 IN PATIENTS WITH SCHISTOSOMIASIS

  • Received:2017-01-09 Revised:2017-01-09 Online:1991-05-31 Published:2017-01-09

摘要: 测定了40例慢性血吸虫病患者外周血粘附细胞和非粘附细胞产生白细胞介素-1(IL-1)和白细胞介素-2(IL-2)的能力。ConA刺激的病人非粘附细胞与正常对照相比,前者产生IL-2能力低下(P0.001)。同时,由于病人Con A刺激后的母细胞对IL-2的吸收低于正常人细胞(P0.01),说明其细胞表面表达的IL-2受体也存在缺损。另一方面,病人LpS刺激的粘附细胞产生的IL-1则与正常对照一致(P0.05)。结果表明,人体随着血吸虫的感染能表现出一种IL-2产生和反应的抑制现象。

关键词: 白细胞介素, 白细胞介素, 粘附细胞, 非粘附细胞

Abstract: The ability of adherent and nonadherent peripheral blood mononuclear cells (PBMC) from forty patients with schistosomiasis to produce IL-1 and IL-2 was studied. The results indicated that ConA-stimulated nonadherent-PBMC from patients exhibited a decreasing ability to produce IL-2 compared with controls (P0.001), and that their ConA-activated blast cells expressed a smaller number of cell surface IL-2 receptor since IL-2 adsorption to the patient cells was lower than that to the normal cells (P0.01). On the other hand, IL-1 production by LpS-stimulated adherent-PBMC from the patients was in agreement with that from the normal controls (P0.05). From above results, it seems that human organism following infection of Schistosoma japonicum might display a sort of supressive phenomenon n the production of and the response to IL-2.