中国寄生虫学与寄生虫病杂志 ›› 1988, Vol. 6 ›› Issue (1): 41-43.

• • 上一篇    下一篇

吡喹酮对卫氏并殖吸虫作用的光镜、电镜及组织化学观察

朱金昌   

  1. 温州医学院病理学教研室
  • 收稿日期:2017-01-10 修回日期:2017-01-10 出版日期:1988-02-28 发布日期:2017-01-10

HISTOPATHOLOGICAL, HISTOCHEMICAL AND ELECTRON MICROSCOPIC OBSERVATION ON THE ADULT WORM OF FARAGONIMUS WESTERMANI AFTER PYQUITON ADMINISTRATION

  • Received:2017-01-10 Revised:2017-01-10 Online:1988-02-28 Published:2017-01-10

摘要: 给感染卫氏并殖吸虫病的犬一次口服吡喹酮100mg/kg 8h后作电镜观察,成虫的外皮层胞质突起缩短,圆形分泌小体空泡变;16~24h后,外皮层、合体细胞、肌细胞、生殖器官及焰细胞的细胞器,特别是线粒体发生重度空泡变等损害。组织化学观察;服药后8h,卵细胞及虫卵中的胚细胞ANAE活性反应减弱;16~24h后,SDH、ACP、ANAE活性明显减弱直至消失。

关键词: 卫氏并殖吸虫, 组织化学观察, 吡喹酮, 肺吸虫, 分泌小体, 外皮层, 粗面内质网, 焰细胞, 生殖器官, 电镜

Abstract: 8 hours after pyquiton treatment at a single dose of 100mg/kg, the cytoplasmic projections of the teguments of P. westermani were shortened, their secretory bodies being decreased. Contraction and swelling of the worms were seen 16-24 hours after treatment. Various organelles of the teguments including syncytia, muscle, genital organs, and the flame cells showed irreversible damage, especially on the mitochondria (Figs. 1-7). The activities of the SDH, ACP and ANAE were gradually reduced and finally disappeared.. The dead worms disintegrated after 3-15 days.