HIV/AIDS合并毕氏肠微孢子虫感染的研究进展

doi:10.12140/j.issn.1000-7423.2022.06.011

中国寄生虫学与寄生虫病杂志 ›› 2022, Vol. 40 ›› Issue (6): 760-766.doi: 10.12140/j.issn.1000-7423.2022.06.011

HIV/AIDS合并毕氏肠微孢子虫感染的研究进展

秦源¹(), 刘华¹, 沈玉娟¹^,²()

1.中国疾病预防控制中心寄生虫病预防控制所（国家热带病研究中心），国家卫生健康委员会寄生虫病原与媒介生物学重点实验室，世界卫生组织热带病合作中心，国家级热带病国际联合研究中心，上海 200025
2.上海交通大学医学院-国家热带病研究中心全球健康学院，上海 200025

收稿日期:2022-05-04 修回日期:2022-08-30 出版日期:2022-12-30 发布日期:2022-12-02
通讯作者: 沈玉娟
作者简介:秦源（1996-），女，硕士研究生，从事肠道原虫分子流行病学研究。E-mail：qy_1226@163.com
基金资助:
国家自然科学基金(82072307);国家自然科学基金(81772224);上海市第五轮公共卫生体系建设三年行动计划重点学科项目(GWV-10.1-XK13)

Research progress on co-infection of Enterocytozoon bieneusi with HIV/AIDS

QIN Yuan¹(), LIU Hua¹, SHEN Yu-juan¹^,²()

1. National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research); NHC Key Laboratory of Parasite and Vector Biology; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases; Shanghai 200025, China
2. School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received:2022-05-04 Revised:2022-08-30 Online:2022-12-30 Published:2022-12-02
Contact: SHEN Yu-juan
Supported by:
National Natural Science Foundation of China(82072307);National Natural Science Foundation of China(81772224);Fifth Round of Three-Year Public Health Action Plan of Shanghai, China(GWV-10.1-XK13)

摘要/Abstract

摘要：

毕氏肠微孢子虫是一种新发机会性感染病原体。人类免疫缺陷病毒（HIV）/获得性免疫缺陷综合征（AIDS）合并毕氏肠微孢子虫感染可导致患者长期持续性腹泻，甚至死亡。近年来HIV/AIDS合并感染毕氏肠微孢子虫的情况引起了研究者的广泛关注，本文就其研究进展作一综述，为毕氏肠微孢子虫感染的预防和控制提供参考。

关键词: 毕氏肠微孢子虫, 人类免疫缺陷病毒/获得性免疫缺陷综合征, 合并感染

Abstract:

Enterocytozoon bieneusi is an emerging pathogen causing opportunistic infections. E. bieneusi coinfection in human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients can causes chronic persistent diarrhea, even death. The co-infection of E. bieneusi has attracted increasing attention in recent years. This paper reviewed the coinfection of E. bieneusi in HIV/AIDS patients, and provided reference for the prevention and control of E. bieneusi infection in HIV/AIDS patients.

Key words: Enterocytozoon bieneusi, Human immunodeficiency virus/acquired immunodeficiency syndrome, Co-infection

中图分类号:

R384.41

秦源, 刘华, 沈玉娟. HIV/AIDS合并毕氏肠微孢子虫感染的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2022, 40(6): 760-766.

QIN Yuan, LIU Hua, SHEN Yu-juan. Research progress on co-infection of Enterocytozoon bieneusi with HIV/AIDS[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2022, 40(6): 760-766.

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地区	感染率/%	基因型	检测方法	参考文献
广西	11.6	GX25、GX456、GX458、pigEBITS7、TypeIV、D、EbpC	分子生物学	[59]
河南	5.7	EbpC、D、Type Ⅳ、Peru8、Peru11、PigEBITS7、EbpD、Henan-Ⅰ、Henan-Ⅱ、Henan-Ⅲ、Henan-Ⅳ、Henan-Ⅴ	分子生物学	[60]

国家	感染率/%	检测方法	参考文献
阿根廷	11.2	分子生物学	[17]
埃塞俄比亚	18.8、15.4	分子生物学	[18-19]
俄罗斯	13.0	免疫学	[20]
法国	6.7	分子生物学	[21]
刚果（金）	7.9	分子生物学	[22]
哥伦比亚	2.9	分子生物学	[23]
加纳	0.8	分子生物学	[24]
加蓬	3.0	免疫学	[25]
津巴布韦	10.1	形态学	[26]
	31.8	分子生物学	[27]
喀麦隆	5.2	形态学	[28]
马来西亚	15.6	分子生物学	[29]
马里	32.0	形态学	[30]
美国	4.5	形态学	[31]
	23.4	分子生物学	[32]
秘鲁	3.9	形态学	[33]
南非	24.1	分子生物学	[34]
尼日利亚	2.6	形态学	[35]
	16.6、5.6、10.5	分子生物学	[36⇓-38]
葡萄牙	42.8	分子生物学	[39]
瑞典	21.7	形态学	[40]
泰国	20.9、5.3	形态学	[41-42]
	5.6	分子生物学	[43]
坦桑尼亚	3.5	形态学	[44]
突尼斯	16.4	分子生物学	[45]
乌干达	28.8	分子生物学	[46]
伊朗	2.2、1.96	分子生物学	[47-48]
意大利	4.2	形态学	[13]
印度	2.5	形态学	[49]
	2.5、1.8、6.7	分子生物学	[50⇓-52]
越南	7.1	分子生物学	[38]

基因组	宿主
基因组	人、兽	人
基因组Ⅰ	A( Ind4、Peru1)、D（Peru9）、CAF1、WL12、WL12-like、HNM-Ⅲ、Peru4(E)、Peru5、Peru6、Peru7、Peru8、Peru10、Peru11、EbpD、EbpA、Ind1、K(type Ⅳ、Peru2）、HAN1	CAF2、CAF3、Peru3、S5、Nig1、Nig2、B(typeⅠ)、Ind2、Ind3、 A (Ind4、Peru1）、N1A1
基因组Ⅴ	无	CAF4
基因组Ⅵ	无	Nig4
未知	无	Nig3、Nig5

HIV/AIDS合并毕氏肠微孢子虫感染的研究进展

Research progress on co-infection of Enterocytozoon bieneusi with HIV/AIDS

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