CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES ›› 2021, Vol. 39 ›› Issue (4): 537-542.doi: 10.12140/j.issn.1000-7423.2021.04.019

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The interplay between Toxoplasma gondii infection and autophagy in host cells

HOU Yong-heng(), LV Fang-li*()   

  1. Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University; Key Laboratory of Tropical Disease Control of Ministry of Education, Sun Yat-sen University, Guangzhou 510080, China
  • Received:2020-11-19 Revised:2021-02-17 Online:2021-08-30 Published:2021-08-05
  • Contact: LV Fang-li E-mail:yongheng_hou@163.com;lvfangli@mail.sysu.edu.cn
  • Supported by:
    National Natural Science Foundation of China(81971955);Natural Science Foundation of Guangdong Province(2019A1515011667);Natural Science Foundation of Guangdong Province(2021A1515012115);2021 Graduate Education Innovation Plan Project of Guangdong Province(2021SFKC003);Undergraduate Teaching Quality Engineering Project of Sun Yat-sen University (SYSU Undergraduate Education [2021]93);Undergraduate Teaching Quality Engineering Project of Sun Yat-sen University (SYSU Undergraduate Education [2020]72);Open Project of Key Laboratory of Tropical Disease Control of Ministry of Education, Sun Yat-sen University(2020ZX02)

Abstract:

Toxoplasma gondii is an important obligate intracellular pathogenic protozoan with worldwide distribution that may cause zoonotic toxoplasmosis, severely impacting the human health and the economy of animal husbandry. Studies have shown that the type I strain of T. gondii can escape from the killing effect of autophagy in host cells by changing the expression of autophagy-related proteins in the host, while the type Ⅱ and Ⅲ strains of T. gondii can be effectively cleared up or suppressed by the autophagy system of host cells. This review provides an update on the interplay between T. gondii infection and host cell autophagy system and the related molecular mechanisms.

Key words: Toxoplasma gondii, Infection, Host cell, Autophagy, Interplay

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