中国寄生虫学与寄生虫病杂志 ›› 2013, Vol. 31 ›› Issue (3): 15-229-234.

• 综述 • 上一篇    下一篇

片形吸虫病研究进展

刘倩,程娜,周岩,许学年*   

  1. 中国疾病预防控制中心寄生虫病预防控制所,卫生部寄生虫病原与媒介生物学重点实验室,世界卫生组织疟疾、血吸虫和丝虫病合作中心,上海200025
  • 出版日期:2013-06-30 发布日期:2013-07-17

Research Progress on Fascioliasis

LIU Qian, CHENG Na, ZHOU Yan, XU Xue-nian*   

  1. National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory of Parasite and Vector Biology, MOH; WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai 200025, China
  • Online:2013-06-30 Published:2013-07-17

摘要: 片形吸虫病(fascioliasis)是由片形吸虫(Fasciola spp.)感染引起的人兽共患病,可导致感染者肝、胆病理损伤;牲畜感染引起产奶、产肉量降低,造成经济损失,是影响中国公共卫生和畜牧业经济发展的重要问题。由于其症状与其他肝胆疾病类似,常被误诊。片形吸虫对三氯苯达唑耐药性的出现成为片形吸虫病防治的重大隐患,寻找敏感特异的诊断方法和有效的药物、疫苗成为片形吸虫病防治的重点。本文综述了片形吸虫病流行概况、诊断、药物治疗与耐药性、疫苗以及组学研究等方面的研究进展

关键词: 片形吸虫病, 三氯苯达唑, 耐药性, 诊断, 疫苗, 组学

Abstract: Fascioliasis is an important zoonosis caused by Fasciola spp. It can cause pathological damages to human liver and gallbladder, as well as economic loss in animal husbandry. Fascioliasis can be easily misdiagnosed with other hepatobiliary diseases. The appearance of resistance to triclabendazole is an issue problem for fascioliasis control. Therefore, research for better diagnostic methods, effective drugs and vaccines become to the focus of fascioliasis control. This article summarizes the progress on epidemiological status, diagnostic method, therapy, drug resistance, vaccine and omics of fascioliasis.

Key words: Fascioliasis, Triclabendazole, Resistance, Diagnosis, Vaccine, Omics