中国寄生虫学与寄生虫病杂志 ›› 1997, Vol. 15 ›› Issue (5): 288-291.

• 论著 • 上一篇    下一篇

感染亚洲不同地域品系日本血吸虫小鼠的肝虫卵肉芽肿大小

何毅勋; 郁琪芳; 胡亚青; 裘丽姝   

  1. 中国预防医学科学院寄生虫病研究所
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1997-10-30 发布日期:1997-10-30

SIZE OF HEPATIC GRANULOMA PRODUCED BY EGGS IN MICE INFECTED WITH VARIOUSGEOGRAPHIC STRAINSOF SCHISTOSOMA JAPONICUM IN ASIA

He Yixun; Yu Qifang; Hu Yaqing; Qiu Lishu   

  1. Institute of Parasitic Diseases; Chinese Academy of Preventive Medicine; WHO Collaborating Centre for Malaria; Schistosomiasis and Filariasis; Shanghai 200025
  • Received:1900-01-01 Revised:1900-01-01 Online:1997-10-30 Published:1997-10-30

摘要: 目的 :了解亚洲不同地域品系日本血吸虫对宿主的致病性。方法 :应用相同宿主 C57BL小鼠在同等条件下感染亚洲 7地域品系日本血吸虫后 ,观察和比较其肝虫卵肉芽肿体积大小。结果 :虽然不同地域品系日本血吸虫对小鼠肝组织所致的虫卵肉芽肿体积大小有异 ,但以亲动物的中国台湾品系所致的单个卵的增生期虫卵肉芽肿平均体积为最小。它与亲人体的中国云南、中国广西、中国四川、中国皖鄂、日本、菲律宾 6地品系所致的增生期虫卵肉芽肿平均体积具有显著性的差别。结论 :中国台湾品系日本血吸虫尾蚴感染宿主后 ,寄生虫与宿主的相互关系可能具有某些独特性 ,或存在免疫应答程度上的差异。

关键词: 日本血吸虫, 品系, 虫卵肉芽肿

Abstract: AIM:To compare the size of hepatic granulomas produced by eggs from various geographic strains of Schistosoma japonicum in Asia.METHODS:The size of each single-egg granuloma of productive stage was measured in the liver sections of C57BL mice infected with each of the following strains of S.japonicum,i.e.,Chinese Yunnan(Y) ,Chinese Guangxi (G) ,Chinese Sichuan (S) ,Chinese Anhui- Hubei (A ) ,Chinese Taiwan (T) , Japanese(J) and the Philippines(P) .The volume of each granuloma was calculated by the formula V =∏AB2/6, in which A and B stand for the two perpendicular axes. RESULTS: In the permissive host C57BL inbred mouse, though the average size of egg granulomas differed with the geographic strains used, themean volume of productive stage of egg granulomas for Chinese Taiwan strains, a zoophilic strain, was smaller than that detected in the other six anthrophophilic strains (Fig. 1). These differences were statistically significant (P < 0. 01). CONCLUSION: Some unique specificities migh t be occurred between the host-parasite relationship in the host infected with Chinese Taiwan strain of S. japonicum and that the immunobiology involved in the hosts would particularly be worth pursuing.

Key words: Schistosoma japonicum, strain, egg granuloma