中国寄生虫学与寄生虫病杂志 ›› 1997, Vol. 15 ›› Issue (5): 276-280.

• 论著 • 上一篇    下一篇

苏北农村人群钩虫感染的流行病学和种群动力学研究

章涛1; 沈一平1; 杨维平2; 邵靖鸥3; 董恺4; 许聚岭2   

  1. 1 南京医科大学寄生虫学教研室; 2 扬州大学医学院寄生虫学教研室; 3 扬州市血吸虫病防治研究所; 4 江都市卫生防疫站
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1997-10-30 发布日期:1997-10-30

EPIDEMIOLOGY AND POPULATION DYNAMICSOF HOOKWORM INFECTION IN A RURAL COMMUNITY OF NORTH JIANGSU PROVINCE

Zhang Tao1; Shen Yiping1; Yang Weiping2; Shao Jing ou3; Dong Kai4; Xu Juling2   

  1. 1 Departmentof Parasitology of Nanjing Medical University, Nanjing210029 2 Departmentof Parasitology of Medical College; Yangzhou University, Yangzhou225001 3 Institute of Antischistosomiasis of Yangzhou City, Yang zhou 2250014 Sanitary and Anti-epidemic Station of Jiangdu City, Jiangdu 225200
  • Received:1900-01-01 Revised:1900-01-01 Online:1997-10-30 Published:1997-10-30

摘要: 目的 :了解钩虫种群传播动力学特征及化疗对其种群传播的影响。方法 :运用数学模型模拟两组人群钩虫感染的种群传播动力学。结果 :显示两组人群钩虫感染的年龄 -感染率和年龄 -感染度总趋势随年龄增长而上升 ,钩虫种群在人群中呈负二项分布 ( Ka=0 .2 89,Kb=0 .2 0 6) ;虫荷与产卵量呈非线性关系 ,存在密度依赖限制作用 ( Za=0 .919,Zb=0 .899) ,基本繁殖率分别为 Ra=2 .153和 Rb=1.872 ;一次化疗 A组和 B组人群阴转率分别为 75.3%和 97.7% ,EPG分别下降92 .7%和 98.6% ,两组人群分别存在再感染。结论 :R值超过传播阈值 ( R0 =1) ,表明当地钩虫感染呈地方性稳定流行 ,在 R值高的流行区化疗遇到的难度较 R值低的流行区大 ,由于再感染 ,一次化疗的效果在长期内得不到巩固 ,在疗效考核中 ,感染度较感染率为更准确合理的指标。

关键词: 钩虫, 感染, 流行病学, 种群动力学, 化疗

Abstract: AIM:To understand the population dynamics of hookworm infection and the effect of
chemotherapy on population transmission. METHODS:The mathematic model was used to simulate the
population dynamics of hookworm infection in the population of Groups A and B.RESULTS:The
changes in age- prevalence and ageintensity (EPG) profile rose with age; the negative binomial
probability model provided a good empirical description of the frequency distribution
ofhookworm burden per host,the K value was0.289 and 0.206, respectively in Groups A and B. There was a non-linear relation ship between worm burden and egg production and this showed density-dependent, the Z value was 0.919 and 0.899, respectively in Groups A and B. The basic reproductive rate R was 2.153 and 1.872, respectively in Groups A and B. CONCLUSION: When R value was greater than the transmission threshold (Ro= 1) , the endemicity of the hookworm infection was stable in the community; the difficulty of control programm emet was higher in the endemic area with high R than with low R, the effect of a single chemotherapy could not be consolidated with in a long period due to reinfection; the effectiveness of chemotherapy should be evaluated by examining the intensity of infection rather than overall prevalence.

Key words: Hookworm, infection, epidemiology, population dynamics, chemotherapy