感染蠕虫后宿主T细胞免疫应答相关信号通路的研究进展

doi:10.12140/j.issn.1000-7423.2022.02.014

摘要/Abstract

摘要：

蠕虫感染普遍存在于亚洲、非洲和南美洲,严重影响人类健康和经济发展。蠕虫感染可启动宿主T细胞免疫应答,影响T细胞增殖与分化。宿主感染蠕虫后,转化生长因子-β/Smad、诱导共刺激分子-诱导共刺激分子配体、程序性死亡蛋白-1/程序性死亡蛋白-1配体、Toll样受体/髓样分化因子88等信号通路可参与T细胞免疫应答,信号分子相互作用可诱导T细胞增殖与分化,进而影响宿主T细胞发挥抗蠕虫感染的作用。本文就宿主感染蠕虫后T细胞免疫应答相关信号通路的研究进展进行综述。

关键词: 蠕虫, 细胞免疫应答, 信号通路

Abstract:

Helminthiasis is highly prevalent in Asia, Africa and South America, seriously affecting human health and economic development. Helminths infection can initiate host T cell immune response, thereby affecting T cell proliferation and differentiation. Some data indicate that in helminth infection, signalling pathways including transforming growth factor-β/Smad(TGF-β/Smad), inducible costimulator-inducible costimulator ligands (ICOS-ICOSL), programmed cell death protein-1/programmed death protein-1 ligand (PD-1/PD-L1), toll-like receptors/myeloid differentiation factor 88 (TLRs/MyD88). can participate in host T cell immune response, the interaction between signalling molecules can induce T cell proliferation and differentiation, then affect the host T cells to play an role in anti-worm infection effect. This article has reviewed the research advances on T cell immune response-related signalling pathways in worm infection.

Key words: Helminth, Cellular immune response, Signalling pathway

中图分类号:

R383

何威, 周必英. 感染蠕虫后宿主T细胞免疫应答相关信号通路的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2022, 40(2): 223-227.

HE Wei, ZHOU Bi-ying. Research progress on signal pathways related to host T cell immune response in helminth infection[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2022, 40(2): 223-227.

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