中国寄生虫学与寄生虫病杂志 ›› 2021, Vol. 39 ›› Issue (6): 836-841.doi: 10.12140/j.issn.1000-7423.2021.06.017

• 综述 • 上一篇    下一篇

疟疾控制与消除中血清学监测方法的研究与应用进展

崔延雯(), 黄芳, 尹建海, 夏志贵*()   

  1. 中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心),国家卫生健康委员会寄生虫病原与媒介生物学重点实验室,世界卫生组织热带病合作中心,国家级热带病国际联合研究中心,上海 200025
  • 收稿日期:2021-04-15 修回日期:2021-05-27 出版日期:2021-12-30 发布日期:2021-11-19
  • 通讯作者: 夏志贵
  • 作者简介:崔延雯(1996-),女,硕士研究生,从事疟疾血清流行病学研究。E-mail: 505237995@qq.com
  • 基金资助:
    上海市公共卫生体系建设三年行动计划第五轮重点学科(GWV-10.1-XK13)

Research and application progress of sero-surveillance methods in malaria control and elimination

CUI Yan-wen(), HUANG Fang, YIN Jian-hai, XIA Zhi-gui*()   

  1. National Center for International Research on Tropical Diseases, Shanghai 200025, China
  • Received:2021-04-15 Revised:2021-05-27 Online:2021-12-30 Published:2021-11-19
  • Contact: XIA Zhi-gui
  • Supported by:
    Fifth Round of Three-Year Public Health Action Plan of Shanghai(GWV-10.1-XK13)

摘要:

准确的监测数据对开展疟疾控制、消除和消除后防止再传播工作至关重要。近年来高灵敏度的血清学监测方法不断发展和优化,特别是基于磁珠和蛋白质芯片的多重免疫分析技术,使得评估低流行区疟疾暴露风险、分析暴露的相关因素和空间异质性等成为可能。本文综述了血清学监测方法在疟疾控制与消除中的研究和应用进展,以为疟疾消除和消除后监测提供更适合的方法学工具。

关键词: 疟疾, 血清学方法, 监测, 控制与消除

Abstract:

Accurate surveillance data is essential for malaria control, elimination and prevention of transmission re-establishment in the post-elimination phase. In recent years, highly sensitive sero-surveillance methods have been developed and optimized, particularly the magnetic bead-based multiplex immunoassay and protein microarray technique, which make it possible to assess the risk of malaria exposure in low-transmission areas, analyze exposure-related factors and spatial heterogeneity. This article reviews the research and application progress of sero-surveillance methods in malaria control and elimination, providing more suitable methodological tools for malaria surveillance in the elimination and post-elimination phase.

Key words: Malaria, Serological methods, Surveillance, Control and elimination

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