中国寄生虫学与寄生虫病杂志 ›› 2021, Vol. 39 ›› Issue (4): 542-547.doi: 10.12140/j.issn.1000-7423.2021.04.020

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蜱类保护性抗原研究进展

吕立红1(), 张金成2, 胡永红1,*()   

  1. 1 河北师范大学生命科学学院,石家庄 050024
    2 石家庄邮电职业技术学院,石家庄 050021
  • 收稿日期:2020-10-05 修回日期:2020-11-06 出版日期:2021-08-30 发布日期:2021-05-28
  • 通讯作者: 胡永红
  • 作者简介:吕立红(1993-),女,硕士研究生,从事基础生态学研究。E-mail: 18835223014@163.com
  • 基金资助:
    教育部春晖计划合作科研项目(Z2017018);河北师范大学重点基金项目(L2020Z06)

Research progress on tick protective antigens

LV Li-hong1(), ZHANG Jin-cheng2, HU Yong-hong1,*()   

  1. 1 College of Life Sciences, Hebei Normal University, Shijiazhuang 050024, China
    2 Shijiazhuang Posts and Telecommunications Technical College, Shijiazhuang 050021, China
  • Received:2020-10-05 Revised:2020-11-06 Online:2021-08-30 Published:2021-05-28
  • Contact: HU Yong-hong
  • Supported by:
    Chunhui Program from the Ministry of Education of China(Z2017018);Foundation of Hebei Normal University(L2020Z06)

摘要:

蜱是一种专性吸血的体外寄生虫,可传播多种病原体,给人类健康和畜牧业发展带来极大危害。筛选高效的保护性抗原用于研制抗蜱疫苗已成为安全有效的蜱类防治新策略。本文简要介绍了商业化的Bm86保护性抗原,着重对蜱类唾液腺、中肠、生殖腺和卵内保护性抗原及酶类、蛋白酶抑制剂、保守性蛋白等不同特性的保护性抗原进行归纳总结,为后续研制抗蜱疫苗提供科学依据。

关键词: 蜱, 保护性抗原, 抗蜱疫苗

Abstract:

Ticks are obligate hematophagous ectoparasites that can transmit a variety of pathogens, having harmful impacts on human health and the husbandry industry. Screening for efficient protective antigens to develop anti-tick vaccines has become a safe and effective strategy for tick control. This paper briefly introduces the commercial Bm86 protective antigen, and summarizes current status of protective antigens with different characteristics derived from tick salivary glands, midgut, gonads and eggs, as well as protective antigens of enzymes, protease inhibitors and conservative proteins. The review will provide a scientific basis for the development of anti-tick vaccines.

Key words: Tick, Protective antigen, Anti-tick vaccine

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