弓形虫感染与宿主细胞自噬的相互作用

doi:10.12140/j.issn.1000-7423.2021.04.019

中国寄生虫学与寄生虫病杂志 ›› 2021, Vol. 39 ›› Issue (4): 537-542.doi: 10.12140/j.issn.1000-7423.2021.04.019

弓形虫感染与宿主细胞自噬的相互作用

侯永恒(), 吕芳丽^*()

中山大学中山医学院寄生虫学教研室,中山大学热带病防治研究教育部重点实验室,广州 510080

收稿日期:2020-11-19 修回日期:2021-02-17 出版日期:2021-08-30 发布日期:2021-08-05
通讯作者: 吕芳丽
作者简介:侯永恒（1989-）,男,博士研究生,从事弓形虫与宿主相互作用研究。E-mail： yongheng_hou@163.com
基金资助:
国家自然科学基金面上项目(81971955);广东省自然科学基金面上项目(2019A1515011667);广东省自然科学基金面上项目(2021A1515012115);2021年广东省研究生教育创新计划项目(2021SFKC003);2021年中山大学校级本科教学质量工程项目（中大教务［2021］93号）;2020年中山大学校级本科教学质量工程项目(中大教务[2020]72 号]);中山大学热带病防治研究教育部重点实验室开放基金(2020ZX02)

The interplay between Toxoplasma gondii infection and autophagy in host cells

HOU Yong-heng(), LV Fang-li^*()

Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University; Key Laboratory of Tropical Disease Control of Ministry of Education, Sun Yat-sen University, Guangzhou 510080, China

Received:2020-11-19 Revised:2021-02-17 Online:2021-08-30 Published:2021-08-05
Contact: LV Fang-li
Supported by:
National Natural Science Foundation of China(81971955);Natural Science Foundation of Guangdong Province(2019A1515011667);Natural Science Foundation of Guangdong Province(2021A1515012115);2021 Graduate Education Innovation Plan Project of Guangdong Province(2021SFKC003);Undergraduate Teaching Quality Engineering Project of Sun Yat-sen University (SYSU Undergraduate Education [2021]93);Undergraduate Teaching Quality Engineering Project of Sun Yat-sen University (SYSU Undergraduate Education [2020]72);Open Project of Key Laboratory of Tropical Disease Control of Ministry of Education, Sun Yat-sen University(2020ZX02)

摘要/Abstract

摘要：

刚地弓形虫（简称弓形虫）呈世界性分布,是重要的专性细胞内致病原虫,可引起人兽共患的弓形虫病,给人群健康和畜牧业生产造成严重的危害。研究发现,Ⅰ型弓形虫株能够逃避宿主细胞自噬的杀伤作用,其机制可能是通过改变宿主自噬相关蛋白的表达水平;而Ⅱ型和Ⅲ型弓形虫株均能被宿主细胞的自噬系统有效地清除或抑制。本文综述了弓形虫感染与宿主细胞自噬相互作用的研究进展及其相关分子机制。

关键词: 刚地弓形虫, 感染, 宿主细胞, 自噬, 相互作用

Abstract:

Toxoplasma gondii is an important obligate intracellular pathogenic protozoan with worldwide distribution that may cause zoonotic toxoplasmosis, severely impacting the human health and the economy of animal husbandry. Studies have shown that the type I strain of T. gondii can escape from the killing effect of autophagy in host cells by changing the expression of autophagy-related proteins in the host, while the type Ⅱ and Ⅲ strains of T. gondii can be effectively cleared up or suppressed by the autophagy system of host cells. This review provides an update on the interplay between T. gondii infection and host cell autophagy system and the related molecular mechanisms.

Key words: Toxoplasma gondii, Infection, Host cell, Autophagy, Interplay

中图分类号:

R382.5

侯永恒, 吕芳丽. 弓形虫感染与宿主细胞自噬的相互作用[J]. 中国寄生虫学与寄生虫病杂志, 2021, 39(4): 537-542.

HOU Yong-heng, LV Fang-li. The interplay between Toxoplasma gondii infection and autophagy in host cells[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2021, 39(4): 537-542.

图/表 1

参考文献 46

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弓形虫感染与宿主细胞自噬的相互作用

The interplay between Toxoplasma gondii infection and autophagy in host cells

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