中国寄生虫学与寄生虫病杂志 ›› 2022, Vol. 40 ›› Issue (6): 786-791.doi: 10.12140/j.issn.1000-7423.2022.06.015

• 综述 • 上一篇    下一篇

阿莫地喹作为抗疟药的研究进展

赵卉1(), 向征1, 周隆参2, 潘茂华2, 杨照青1()   

  1. 1.昆明医科大学,昆明,650500
    2.上林县人民医院,广西,530000
  • 收稿日期:2022-04-22 修回日期:2022-10-10 出版日期:2022-12-30 发布日期:2022-12-21
  • 通讯作者: 杨照青
  • 作者简介:赵卉(1996-),女,博士研究生,从事疟原虫抗药性研究。E-mail: 18435226968@163.com
  • 基金资助:
    国家自然科学基金(U1802286);国家自然科学基金(31860604);云南省科技厅科技计划项目(202003AE140004);广西壮族自治区卫生健康委员会科研项目(ZA20221274)

Research progress of amodiaquine as an antimalarial drug

ZHAO Hui1(), XIANG Zheng1, ZHOU Long-can2, PAN Mao-hua2, YANG Zhao-qing1()   

  1. 1. Kunming Medical University, Kunming 650500, China
    2. The People’s Hospital of Shanglin, Guangxi 530000, China
  • Received:2022-04-22 Revised:2022-10-10 Online:2022-12-30 Published:2022-12-21
  • Contact: YANG Zhao-qing
  • Supported by:
    National Science Foundation of China(U1802286);National Science Foundation of China(31860604);Science and Technology Planning Project of Yunnan Science and Technology Department(202003AE140004);Research Project of Health Commission of Guangxi Zhuang Autonomous Region(ZA20221274)

摘要:

疟疾是由疟原虫引起的严重危及人类生命的传染病。疟疾的治疗及防控主要依赖抗疟药物。阿莫地喹是重要的治疗和预防疟疾的药物,与青蒿素衍生物相配合,在非洲疟疾流行的许多国家用作一线治疗药物。本文对阿莫地喹独特的抗疟活性、抗疟效果、抗药性分子标记和安全性进行了综述。

关键词: 阿莫地喹, 疟疾

Abstract:

Malaria is a serious, life-threatening infectious disease caused by the Plasmodium parasite. The treatment and prevention of malaria mainly rely on antimalarial drugs. Amodiaquine is an important drug for the treatment and prevention of malaria. It is used in combination with artemisinin dericatives as a first-line treatment drug in many countries where malaria is endemic including Africa. This article reviews the unique antimalarial activity, treatment outcomes, molecular markers for drug resistance and safety of amodiaquine.

Key words: Amodiaquine, Malaria

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