中国寄生虫学与寄生虫病杂志 ›› 2018, Vol. 36 ›› Issue (2): 174-177.

• 综述 • 上一篇    下一篇

刚地弓形虫toxofilin蛋白的研究进展

刘功振1, 刘源璟1, 彭祥云2, 寇景轩1,*()   

  1. 1 山东省医学科学院,山东省寄生虫病防治研究所,济宁 272033
    2 临沂市河东畜牧局,临沂 276000
  • 收稿日期:2017-08-04 出版日期:2018-04-28 发布日期:2018-04-24
  • 通讯作者: 寇景轩
  • 基金资助:
    国家自然科学基金(No. 31502057,No. 81501770);山东省医学科学院医药卫生科技创新工程(No. 201608);山东省重点研发计划项目(No. GG201709280131);山东省医药卫生科技发展计划(No. 2017WS104)

Research advances on the Toxoplasma gondii toxofilin protein

Gong-zhen LIU1, Yuan-jing LIU1, Xiang-yun PENG2, Jing-xuan KOU1,*()   

  1. 1 Shandong Institute of Parasitic Diseases, Shandong Academy of Medical Sciences, Jining 272033, China
    2 Hedong District Animal Husbandry Bureau of Linyi City, Linyi 276000, China
  • Received:2017-08-04 Online:2018-04-28 Published:2018-04-24
  • Contact: Jing-xuan KOU
  • Supported by:
    Supported by National Natural Science Foundation of China (No. 31502057, No. 81501770);Innovation Project of Shandong Academy of Medical Sciences (No. 201608);Shandong Province Key Research and Development Projects (No. GG201709280131);Shandong Province Medical and Health Science and Technology Development Plan (No. 2017WS104)

摘要:

Toxofilin是刚地弓形虫棒状体蛋白家族成员,但该蛋白有一定的特殊性,其结构中不存在棒状体蛋白典型丝氨酸、苏氨酸激酶区。Toxofilin分泌到宿主细胞质中,能与磷酸脂酶2C(PP2C)、肌动蛋白(actin)相互作用,形成toxofilin-actin-PP2C三聚体复合物,被酪蛋白激酶Ⅱ(CKⅡ)和PP2C激活发生磷酸化,在弓形虫入侵细胞过程中发挥重要作用。本文综述了弓形虫toxofilin的发现及其功能和免疫保护性等方面的研究进展。

关键词: 刚地弓形虫, Toxofilin, 肌动蛋白, 磷酸脂酶2C, 酪蛋白激酶Ⅱ

Abstract:

Toxofilin is a member of the Toxoplasma gondii rhoptry protein family with a unique property of lack of a typical serine/threonine kinase domain for rhoptrys. Toxofilin secreted into host cytoplasm can interact with phosphopeptide 2C (PP2C) and actin to form a toxofilin-actin-PP2C trimer complex. Toxofilin is phosphorylated upon activation by casein kinase Ⅱ (CKⅡ) and PP2C, which plays an important role during its invasion. This review summarizes the discovery and research advances on function and immune-protection of toxofilin.

Key words: Toxoplasma gondii, Toxofilin, Actin, Phosphatase 2C, Casein kinase Ⅱ

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