中国寄生虫学与寄生虫病杂志 ›› 2017, Vol. 35 ›› Issue (3): 294-299.

• 综述 • 上一篇    下一篇

长链非编码RNA在寄生虫中的研究进展

于爱萍, 沈玉娟*()   

  1. 中国疾病预防控制中心寄生虫病预防控制所,世界卫生组织热带病合作中心,科技部国家级热带病国际联合研究中心,卫生部寄生虫病原与媒介生物学重点实验室,上海 200025
  • 收稿日期:2016-12-29 出版日期:2017-03-30 发布日期:2017-09-07
  • 通讯作者: 沈玉娟
  • 基金资助:
    国家自然科学基金(No. 81371842)

Research progress on long non-coding RNA in parasitology

Ai-ping YU, Yu-juan SHEN*()   

  1. National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention
    WHO Collaborating Centre for Tropical Diseases
    National Center for International Research on Tropical Diseases, Ministry of Science and Technology
    Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai 200025, China
  • Received:2016-12-29 Online:2017-03-30 Published:2017-09-07
  • Contact: Yu-juan SHEN
  • Supported by:
    Supported by the National Natural Science Foundation of China(No. 81371842)

摘要:

【提要】 长链非编码RNA(long non-coding RNA, lncRNA)是一类转录本长度大于200 nt,缺乏蛋白质编码功能的RNA分子。LncRNA在多种生物学进程中发挥重要的调节功能,广泛参与细胞增殖、分化、代谢、凋亡等重要的生理活动。LncRNA在寄生虫发育、代谢、生理和致病机制中也发挥重要作用。本文就lncRNA在寄生虫学研究中的进展作一综述。

关键词: 长链非编码RNA, 寄生虫, 基因表达

Abstract:

Long non-noncoding RNAs(1ncRNAs) are defined as non-protein coding transcripts longer than 200 nucleotides. LncRNAs play important regulatory roles in multiple biological processes, and participate in cell proliferation, differentiation, metabolism, apoptosis, etc. LncRNAs play also important for the development, metabolism, physiology, and pathology of parasites. This review summarizes the research progress of lncRNAs in parasitology.

Key words: Long non-coding RNA, Parasite, Gene expression

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