中国寄生虫学与寄生虫病杂志 ›› 2017, Vol. 35 ›› Issue (2): 180-184.

• 综述 • 上一篇    下一篇

寄生虫微管蛋白的研究进展

姚嘉青, 刘丛珊, 张皓冰*()   

  1. 中国疾病预防控制中心寄生虫病预防控制所,世界卫生组织热带病合作中心,科技部国家级热带病国际联合研究中心,卫生部寄生虫病原与媒介生物学重点实验室,上海 200025
  • 收稿日期:2016-09-23 出版日期:2017-04-20 发布日期:2017-05-02
  • 通讯作者: 张皓冰
  • 基金资助:
    国家自然科学基金(No. 81401691);上海市卫计委面上项目(No. 201540170);国家国际科技合作专项项目(No. 2014DFA31130)

Progress on parasite tubulin

Jia-qing YAO, Cong-shan LIU, Hao-bing ZHANG*()   

  1. National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention WHO Collaborating Centre for Tropical Diseases National Center for International Research on Tropical Diseases, Ministry of Sciences and Technology Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai 200025, China
  • Received:2016-09-23 Online:2017-04-20 Published:2017-05-02
  • Contact: Hao-bing ZHANG
  • Supported by:
    Supported by the National Natural Science Foundation of China (No. 81401691), the General Program of Shanghai Municipal Health Bureau (No. 201540170) and the International Science and Technology Cooperation (No. 2014DFA31130)

摘要:

寄生虫严重影响人类和牲畜健康,因此亟需有效药物控制和治疗寄生虫疾病。其中以微管蛋白为靶标的抗寄生虫药物已受到广大科研工作者的关注。本文对近年寄生虫微管蛋白特征及其与药物作用机制、抗药性和实验方法相关的研究作一综述,旨在为探索抗寄生虫新型药物提供理论参考。

关键词: 寄生虫, 微管蛋白, 抑制剂, 作用机制, 抗药性, 实验方法

Abstract:

Parasites threaten the health of humans and animals, so there is an imperative need for pharmaceutical control and treatment of parasitic infection. The anti-parasite drugs targeting the microtubules of parasites have attracted much attention. In this article, we summarize the properties of microtubules, their interactions with drugs, resistance to drugs, as well as the experimental methods, in order to provide theoretical basis for exploring new anti-parasite drugs.

Key words: Parasite, Tubulin, Inhibitor, Mode of action, Drug resistance, Experimental methods

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