中国寄生虫学与寄生虫病杂志

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寄生虫感染对类风湿性关节炎保护作用的研究进展

沙地克·阿帕尔,吐尔洪江·吐逊,温浩*   

  1. 新疆医科大学第一附属医院消化血管外科中心肝(移植)·腹腔镜外科;新疆医科大学第一附属医院临床医学研究院新疆包虫病基础医学重点实验室,乌鲁木齐830054
  • 出版日期:2016-02-28 发布日期:2016-03-11

Research Development on the Protective Effect of Parasitic Infection against Rheumatoid Arthritis

Shadike Apaer, Tuerhongjiang Tuxun, WEN Hao*   

  1. Department of Liver and Laparoscopic Surgery, Digestive and Vascular Centre; State Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis; The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
  • Online:2016-02-28 Published:2016-03-11

摘要:

类风湿性关节炎是影响人类健康的全球性卫生问题,其发病率不断增长。自从1870年“卫生假说”的提出,有大量实验和流行病学研究结果提示寄生虫感染可能减轻或改善类风湿性关节炎机体的病情,但其具体机制尚未明确。因此,研究寄生虫感染与类风湿性关节炎的关系具有重要意义。本文将初步探讨寄生虫感染对类风湿性关节炎的保护作用及其可能的细胞及细胞因子变化等免疫机制。

关键词: 类风湿性关节炎, 寄生虫, 免疫应答

Abstract:

Rheumatoid arthritis is a global disease with an increasing incidence. Although increasing experimental and epidemiological studies have suggested the potential therapeutic effects of parasitic infection on rheumatoid arthritis since the proposition of Hygiene Hypothesis in 1870, the exact mechanisms remain unknown. Thus, it is of great significance to study the relationship between parasitic infection and rheumatoid arthritis. This review is to discuss the relationship between parasitic infection and rheumatoid arthritis and the mechanisms which may involve cell immunity and cytokine alterations.

Key words: Rheumatoid arthritis, Parasite, Immune response