中国寄生虫学与寄生虫病杂志

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树突状细胞在蠕虫感染免疫应答中的作用

姜晶1,2,赵权2,杨桂连1 *   

  1. 1 吉林农业大学动物科学技术学院,吉林省动物微生态制剂工程研究中心,长春 130118;2 长春科技学院动物科技学院,长春 130600
  • 出版日期:2015-04-30 发布日期:2015-05-04

The Role of Dendritic Cells in Host Immunity against Helminth Infections

JIANG Jing1,2,ZHAO Quan2,YANG Gui-lian1 *   

  1. College of Animal Science and Technology,Jilin Agricultural University;Jilin Provincial Engineering Research Center of Animal Proboscis,Changchun 130118,China;2 College of Animal Science and Technology,Changchun University of Science and Technology,Changchun 130600,China
  • Online:2015-04-30 Published:2015-05-04

摘要:

树突状细胞是体内功能最强的专职抗原呈递细胞。寄生性蠕虫感染不但能促进树突状细胞分化成熟,诱导机体产生Th2型免疫应答,还能抑制树突状细胞正常功能,诱导免疫逃避。本文对树突状细胞在蠕虫感染免疫中的作用进行综述。

关键词:  ,  ,  , 树突状细胞, 蠕虫, 免疫调节, Toll样受体

Abstract:

 Dendritic cells are the strongest professional antigen-presenting cells. Helminth infection could promote maturation of immature dendritic cells, induce Th2-type immune responses, and inhibit the normal function of dendritic cells which is closely associated with the immune evasion. This paper reviews the role of dendritic cells in host immunity against helminth infections.

Key words: Dendritic cell, Helminth, Immunoregulation, Toll like receptor