中国寄生虫学与寄生虫病杂志 ›› 2014, Vol. 32 ›› Issue (2): 12-143-147.

• 综述 • 上一篇    下一篇

CD8+ T细胞免疫应答在刚地弓形虫感染免疫中的功能研究进展

吴斌,吕芳丽*   

  1. 中山大学中山医学院寄生虫学教研室;热带病防治研究教育部重点实验室,广州 510080
  • 出版日期:2014-04-30 发布日期:2014-07-03

Progress of CD8+ T Cell-Mediated Immune Response to Toxoplasma gondii Infection

WU Bin, LYU Fang-li *   

  1. Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University; Key Laboratory of Tropical Disease Control, Ministry of Education, Guangzhou 510080, China
  • Online:2014-04-30 Published:2014-07-03

摘要: 刚地弓形虫(Toxoplasma gondii)是一种专性细胞内寄生原虫,能感染包括人在内的多种温血动物。免疫功能正常的机体感染弓形虫后,大多表现为隐性感染;但免疫功能低下的机体感染弓形虫后,可引起严重的弓形虫病。T细胞介导的免疫应答在控制弓形虫感染中发挥着重要的作用。本文就CD8+ T细胞免疫应答在弓形虫感染方面的研究进展作一综述。

关键词: 弓形虫感染, CD8+ T细胞, 免疫应答

Abstract: Toxoplasma gondii is an obligate intracellular protozoan parasite, which infects warm-blooded animals including humans. T. gondii infection in the immune-competent individual is largely asymptomatic, but it can cause severe toxoplasmosis in immune-deficiency patients. T cell-mediated immunity plays an important role in resistance against T. gondii. Therefore, this review focuses on the progress of CD8+ T cell-mediated immune response to T. gondii infection.

Key words: Toxoplasma gondii infection, CD8+ T cell, Immune response