中国寄生虫学与寄生虫病杂志 ›› 2013, Vol. 31 ›› Issue (5): 16-406-409.

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寄生性蠕虫组织蛋白酶F研究进展

曲自刚,付宝权*   

  1. 中国农业科学院兰州兽医研究所,家畜疫病病原生物学国家重点实验室,农业部兽医公共卫生重点开放实验室,甘肃省动物寄生虫病重点实验室,兰州730046
  • 出版日期:2013-10-30 发布日期:2014-07-24

Research Progress on Cathepsin F of Parasitic Helminths

QU Zi-gang,FU Bao-quan*   

  1. State Key Laboratory of Veterinary Etiological Biology;Key Laboratory of Veterinary Public Health of the Ministry of Agriculture;Key Laboratory of Veterinary Parasitology of Gansu Province;Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730046,China
  • Online:2013-10-30 Published:2014-07-24

摘要: 组织蛋白酶F(cathepsin F)是半胱氨酸蛋白酶家族木瓜蛋白酶亚家族的重要成员。寄生性蠕虫组织蛋白酶F可水解半胱氨酸蛋白酶特异性底物,降解血红蛋白等宿主蛋白作为营养物质,参与虫体入侵,且具有免疫反应性,可作为寄生虫病免疫诊断、疫苗研制和抗寄生虫药物筛选的潜在靶点,对寄生虫病防治具有重要意义。本文综述了组织蛋白酶F的结构特征、作用机制及寄生性蠕虫组织蛋白酶F的研究进展。

关键词: 寄生性蠕虫, 组织蛋白酶F, 酶活性, 免疫反应性

Abstract: Cathepsin F is an important member of papain-like subfamily in cysteine protease family. Cathepsin F of helminth parasites can hydrolyze the specific substrate, degrade host protein such as hemoglobin for nutrition, and be involved in invasion into host tissue. Therefore, cathepsin F serves as a potential target for parasitic disease immunodiagnosis, vaccine design and anti-parasite drug screening. This article reviews the structural characteristics and mechanisms of cathepsin F, and research advances on cathepsin F of parasitic helminths.

Key words: Parasitic helminth, Cathepain F, Enzymatic activity, Immunoreactivity