中国寄生虫学与寄生虫病杂志 ›› 2013, Vol. 31 ›› Issue (4): 19-327-328.

• 研究简报 • 上一篇    下一篇

宁波地区2 769例疑似过敏性疾病患儿过敏原检测

刘文渊1, 2,周江瑾3   

  1. 1 浙江大学公共卫生学院,杭州 310012;2 宁波市妇女儿童医院检验科,宁波 315012;3 宁波市妇女儿童医院儿科,宁波 315012
  • 出版日期:2013-08-30 发布日期:2013-12-27

Allergen Detection among 2 769 Children with Allergic Symptoms in Ningbo Area

LIU Wen-yuan1, 2,ZHOU Jiang-jin3   

  1. 1 School of Public Health,Zhejiang University,Hangzhou 310012,China;2 Department of Clinical Laboratory,Ningbo Women & Children′s Hospital,Ningbo 315012,China;3 Department of Pediatrics,Ningbo Women & Children′s Hospital,Ningbo 315012,China
  • Online:2013-08-30 Published:2013-12-27

摘要: 采用免疫印迹法(immunoblotting test,IBT)对宁波市妇女儿童医院2010年10月至2011年12月疑似过敏性疾病患儿14类过敏原进行检测。共检测患儿2 769例,总特异性IgE抗体(sIgE)阳性率为76.0%(2 105/2 769),其中,男性sIgE阳性率(80.0%,1 344/1 679)高于女性(69.8%,761/1 090)(P<0.05)。居前3位的过敏原分别为户尘螨/粉尘螨(33.2%)、牛奶(12.6%)和真菌(12.6%)。2011年4个季度户尘螨/粉尘螨的检出率分别为19.4%(79/407)、 33.9%(196/564)、 39.3%(222/565)和 36.0%(275/763),4个季度间差异有统计学意义(P<0.05)。主要的4类过敏原(户尘螨/粉尘螨、牛奶、真菌类和鸡蛋)不同年龄组间的阳性率差异均有统计学意义(P<0.05)。户尘螨/粉尘螨阳性级别以3~6级为主(66.8%,613/918)。

关键词: 儿童, 过敏原检测, IgE, 免疫印迹法

Abstract: A total of 2 769 children with allergic disease were admitted from October 2010 to December in Ningbo Women & Children′s Hospital. Fourteen kinds of serum specific-IgE were detected by immunoblotting method. Among the 2 769 children, the total positive rate of sIgE was 76.0%(2 105/2 769). The sIgE positive rate in males (80.0%, 1 344/1 679) was significantly higher than that of females(69.8%, 761/1 090)(P<0.05). The top three allergens were dust mites(33.2%), milk(12.6%) and fungi(12.6%). There were statistical differences of positive reaction to dust mites among 4 seasons(19.4%, 33.9%, 39.3%, 36.0%)(P<0.05). Significant differences were found in the positive rates of dust mites, milk, fungi, and egg among the age groups(P<0.05). The level of dust mite specific IgE were mainly in grade 3-6(613/918, 66.8%).

Key words:  , Children;Allergen detection;IgE;Immunoblotting