中国寄生虫学与寄生虫病杂志 ›› 2013, Vol. 31 ›› Issue (3): 17-238-241.

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寄生虫病原相关分子模式的研究进展

杨庆利1,2 *,申继清3   

  1. 1 广西壮族自治区疾病预防控制中心寄生虫病防制所,南宁530028;2 中国疾病预防控制中心寄生虫病预防控制所,卫生部寄生虫病原与媒介生物学重点实验室,世界卫生组织疟疾、血吸虫病和丝虫病合作中心,上海 200025;3 广西医科大学寄生虫学教研室,南宁530021
  • 出版日期:2013-06-30 发布日期:2013-07-17

Pathogen Associated Molecular Patterns of Parasite

YANG Qing-li1 *, SHEN Ji-qing2   

  1. 1 Institute of Parasitic Diseases,Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention,Nanning 530028,China;2 National Institute of Parasitic Diseases,Chinese Center for Disease Control and Prevention; Key Laboratory of Parasite and Vector Biology,MOH; WHO Collaborating Center for Malaria,Schistosomiasis and Filariasis,Shanghai 200025,China; 3 Department of Parasitology,Guangxi Medical University,Nanning 530021,China
  • Online:2013-06-30 Published:2013-07-17

摘要: 随着对传统病原微生物的病原相关分子模式(pathogen associated molecular patterns, PAMPs)认识的深入,发现寄生虫PAMPs存在的线索。寄生虫PAMPs在分子结构、与受体的结合方式、胞内信号转导途径和诱导效应等方面与传统PAMPs均有所差异。本文从上述方面综述了寄生虫PAMPs的研究进展。

关键词: 寄生虫, 病原相关分子模式, 模式识别受体, 天然免疫

Abstract: With the research progress of classical pathogen associated molecular patterns(PAMPs) from pathogenic microbes, the presence of the parasite PAMPs has been confirmed. The parasite PAMPs show some differences from classical PAMPs in molecular structures, receptor binding ways, intracellular signal transduction pathways, and induced effects. This review focuses on the issues of parasite PAMPs.

Key words: Parasite, Pathogen associated molecular pattern, Pattern recognition receptor, Innate immunity