中国寄生虫学与寄生虫病杂志 ›› 2012, Vol. 30 ›› Issue (1): 16-71-72.

• 研究简报 • 上一篇    下一篇

阿苯达唑对曼氏裂头蚴感染小鼠的疗效观察

崔晶,王明明,赵雨薇,甘冠华,胡博文,姜鹏,祁欣,刘莉娜,王中全*   

  1. 郑州大学医学院寄生虫学教研室,郑州 450052
  • 出版日期:2012-02-29 发布日期:2012-09-28

Efficacy of Ablendazole for Treatment of Mice Infected  with Sparganum mansoni

CUI Jing,WANG Ming-ming,ZHAO Yu-wei,GAN Guan-hua,HU Bo-wen,JIANG Peng,QI Xin,LIU Li-na,WANG Zhong-quan*   

  1. Department of Parasitology,Medical College,Zhengzhou University,Zhengzhou  450052,China
  • Online:2012-02-29 Published:2012-09-28

摘要: 为观察不同剂量阿苯达唑对感染曼氏裂头蚴小鼠的疗效,将72只小鼠随机均分为A~H等8组,每鼠经口感染5条裂头蚴。感染后1周,A~C组小鼠应用阿苯达唑灌胃治疗1个疗程(2 次/d×7 d),阿苯达唑1个疗程的总剂量分别为1 700、2 500和3 300 mg/kg,治疗后1周剖杀;E~G组小鼠治疗1个疗程后间隔7 d,再治疗1个疗程,总剂量同A~C组,第2疗程结束后1周剖杀;D、H组小鼠仅灌服蒸馏水,分别作为A~C组和E~G组小鼠的对照组。检获裂头蚴,计算各组小鼠的平均虫数和减虫率。结果发现,A~C组小鼠的减虫率分别为20.0%、20.0%和24.9%,差异无统计学意义(χ2=0.351,P>0.05)。E~G组小鼠的减虫率分别为22.3%、36.4%和31.9%,差异亦无统计学意义(χ2=1.812,P>0.05);应用相同阿苯达唑剂量治疗1个与2个疗程后,小鼠减虫率的差异均无统计学意义(P>0.05)。表明阿苯达唑对裂头蚴感染小鼠无明显的治疗效果。

关键词:  , 曼氏裂头蚴;裂头蚴病;治疗;阿苯达唑;小鼠

Abstract: In order to observe the efficacy of albendazole for the treatment of mice infected with Sparganum mansoni,a total of 72 mice were divided into 8 groups (9 mice each),each mouse was orally infected with 5 plerocercoid. At one week after infection,groups A-C were treated with a 7-day course of albendazole (1 700,2 500,and 3 300 mg/kg,twice daily),and sacrificed at 1 week post-treatment;groups E-G were treated with the second course of albendazole with the same dosage at 1 week interval after the first course,and sacrificed at 1 week after the second course;the groups D and H were used as control for A-C and E-G,respectively. After the infected mice were sacrificed,the mean number of worms recovered was observed and worm reduction rate was determined. When treating with one course of albendazole at 1 week post in-fection,the worm reduction rate in groups A-C was 20.0%,20.0% and 24.9%,respectively (χ2=0.351,P>0.05). After treatment with two courses of albendazole,the worm reduction rate in groups E-G was 22.3%,36.4% and 31.9% (χ2=1.812,P>0.05). The difference of the worm reduction rate in the infected mice treated with 1 and 2 courses of albendazole showed no statistical significance (P>0.05). The results indicated albendazole has no obvious efficacy for treating sparganosis in mice.

Key words: Sparganum mansoni, Sparganosis, Treatment, Albendazole, Mouse