中国寄生虫学与寄生虫病杂志 ›› 2011, Vol. 29 ›› Issue (4): 15-310-313、318.

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骨桥蛋白与肝棘球蚴病关系的研究进展

 张永国, 张示杰   

  1. 石河子大学医学院第一附属医院肝胆外科,石河子 832008
  • 出版日期:2011-08-30 发布日期:2012-09-27

Research Progress on the Relationship between Osteopontin and Hepatic Echinococcosis

 ZHANG  Yong-Guo, ZHANG  Shi-Jie   

  1. Department of General Surgery, The First Affiliated Hospital, Medical College of Shihezi University, Shihezi 832008, China
  • Online:2011-08-30 Published:2012-09-27

摘要:  骨桥蛋白是一种带负电荷、具有亲水性的分泌型磷酸化糖蛋白,由多种组织细胞合成与分泌,存在于体内多种组织和细胞中。该蛋白结构上与多种基质蛋白相似,功能上具有细胞因子的特点,参与了机体多种病理过程。近年来的研究证实,骨桥蛋白在肝棘球蚴的外囊中大量表达,并在其形成过程中起重要作用。

关键词:  , 骨桥蛋白;棘球蚴病;肝脏

Abstract: Osteopontin is a negatively charged, hydrophilic secreted phosphorylated glycoprotein. It is synthesized and secreted by a variety of cells, and is found in various tissues and cells. The protein is similar in structure to matrix proteins, has the characteristics of cytokines in function and invovled in a series of pathological processes. Recent studies confirmed that osteopontin is highly expressed in liver hydatid cyst and may play an important role in cyst formation.

Key words: Osteopontin, Echinococcosis, Liver