中国寄生虫学与寄生虫病杂志 ›› 2006, Vol. 24 ›› Issue (6): 14-465.

• 综述 • 上一篇    下一篇

隐孢子虫线粒体研究进展

王进产*;张龙现;宁长申;菅复春;邵兆霞;石团员   

  1. 河南农业大学牧医工程学院 郑州 450002* 现工作单位: 洛阳普莱柯生物工程公司
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2006-12-30 发布日期:2006-12-30
  • 通讯作者: 张龙现

The Advancement on Mitochondrion of Cryptosporidium

WANG Jin-chan*;ZHANG Long-xian;NING Chang-shen;Fu-chun;
SHAO Zhao-xia;SHI Tuan-yuan
  

  1. College of Animal Science and Veterinary Medicine,Henan Agricultural University,Zhengzhou 450002,China
  • Received:1900-01-01 Revised:1900-01-01 Online:2006-12-30 Published:2006-12-30

摘要: 隐孢子虫病是一种重要的人兽共患的原虫病,目前尚无用于治疗隐孢子虫病的特效药物。线粒体是真核生物中拥有蛋白和酶最多的细胞器,因而隐孢子虫线粒体也可能成为药物潜在的作用靶位。最近一些研究表明隐孢子虫存在线粒体诱生的细胞器,但和其他原生动物的线粒体存在着差异。隐孢子虫具有退化的线粒体,但缺少线粒体基因组,完全依赖核基因来编码所需的功能蛋白。本文对隐孢子虫线粒体存在的依据及其可能具有的功能作一综述。

关键词: 隐孢子虫, 线粒体

Abstract: Cryptosporidiosis is an important apicomplexan disease with medical and veterinary significance. There is still no effective drug for its control. Mitochondrion is an organelle which contains most protein and enzyme in eukaryotes, so the mitochondrion of Cryptosporidium may be a potential target of drugs. Recent studies provided evidence for a mitochondrial derived compartment in this parasite. But the organelle has some difference to that of other apicomplexan parasites. This organelle appears to lack its genome, and thus must be entirely dependent on nuclear-encoded proteins. This article reviews the evidence for the organelle in Cryptosporidium and its probable function.

Key words: Cryptosporidium, Mitochondrion