中国寄生虫学与寄生虫病杂志 ›› 2006, Vol. 24 ›› Issue (6): 13-460.

• 综述 • 上一篇    下一篇

溶组织内阿米巴致病因子的研究进展

陈奕 综述;程训佳 审校   

  1. 复旦大学上海医学院病原生物系,上海 200032
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2006-12-30 发布日期:2006-12-30

Advances in Research on Virulence Factors of Entamoeba histolytica

CHEN Yi;CHENG Xun-jia   

  • Received:1900-01-01 Revised:1900-01-01 Online:2006-12-30 Published:2006-12-30

摘要: 溶组织内阿米巴滋养体入侵宿主,聚集在结肠,可以穿过覆盖在结肠上皮的黏液层,引起阿米巴性结肠炎;或者随血液循环进入其他组织,引起肠外脓肿。本文就溶组织内阿米巴滋养体致病因子及其作用作一综述。

关键词: 溶组织内阿米巴, 致病因子, 凝集素, 阿米巴穿孔素, 半胱氨酸蛋白酶

Abstract: The parasitic protozoan Entamoeba histolytica is an important pathogen responsible for intestinal and extraintestinal amebiasis in human, claiming up to 100 000 victims every year. This parasite is characterized by its high potential for invading and destroying human tissues. Invasion past the mucous barrier of the colonic epithelium leads to the development of colitis and amebic dysentery. Dissemination of the trophozoite through blood stream permits the invasion of other tissues, resulting in abscesses in extracolonic location. Several virulence factors have been proposed to be involved in E. histolytica pathogenicity. This review is to summarize the advances in the research.

Key words: Entamoeba histolytica, Virulence factor, Lectin, Amoebapore, Cysteine proteinase