中国寄生虫学与寄生虫病杂志 ›› 2000, Vol. 18 ›› Issue (5): 9-292.

• 论著 • 上一篇    下一篇

血吸虫病患者治疗前后特异性IgG4抗体的观察

冯正;裘丽姝;张永红;李浩
  

  1. 中国预防医学科学院寄生虫病研究所,上海 200025
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2000-10-30 发布日期:2000-10-30

OBSERVATION ON SPECIFIC IgG4 ANTIBODY OF SCHISTOSOMIASIS PATIENTS BEFORE AND AFTER TREATMENT

FENG Zheng;QIU Li shu;ZHANG Yong hong;LI Hao
  

  1. Institute of Parasitic Diseases;Chinese Academy of Preventive Medicine **;Shanghai 200025
  • Received:1900-01-01 Revised:1900-01-01 Online:2000-10-30 Published:2000-10-30

摘要:   [目的 ]观察血吸虫病患者治疗前后特异性IgG4抗体的变化。[方法 ]ELISA法。 [结果 ]2 7例血吸虫病患者治疗前SEA IgG4和AWA IgG4阳性率分别为 96 3%和 10 0 % ,平均OD值分别为 1 6 2和 0 72。治疗后 6月复查 18例 ,阳性率分别为 94 4%和 10 0 % ,平均OD值分别为 1 0 6和 0 5 6。治疗后 12月复查 2 7例 ,阳性率分别为 96 3%和 92 6 % ,平均OD值分别为 0 99和 0 5 8。 [结论 ]2 7例血吸虫病患者SEA IgG4和AWA IgG4治疗前后阳性率无明显变化 ,但抗体水平有所下降。

关键词: 血吸虫病, 抗体, IgG4, ELISA

Abstract:  Objective] To observe the alteration of specific IgG4 antibody of schistosomiasis patients before and after treatment. [Methods] ELISA. [Results] The SEA IgG4 and AWA IgG4 positive rates of 27 schistosomiasis cases were 96 3% and 100%, respectively,their average OD values were 1 62 and 0 72. 6 months post treatment 18 cases were followed up, the positive rates were 94 4% and 100%, respectively, their average OD values were 1 06 and 0 56, respectively. 12 months post treatment all cases were followed up, the positive rates of SEA IgG4 and AWA IgG4 were 96 3% and 92 6%, resepectively ,their average OD values were 0 99 and 0 58, respectively. [Conclusion] No obvious changes were found in the SEA IgG4 and AWA IgG4 positive rates of 27 schistosomiasis cases before and after treatment, whereas the antibody level of specific IgG4 was decreased.

Key words: schistosomiasis, antibody, IgG4, ELISA